Vacation rentals in Defiance

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Top-rated vacation rentals in Defiance

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Guest favorite

Tiny home in Pacific

4.96 out of 5 average rating, 161 reviews

Route 66 railroad shanty, a cozy artsy small space

This 536 s.f. house, believed to have once been a sleeping shanty for railroad crews switching shifts for the night. Fully renovated and updated in 2021 by a local artist, you will find custom metal art throughout, granite countertops and a very warm cabin feel featuring a kitchen and bathroom finished with locally sourced Missouri dark red cedar, 10 minutes from six flags, Purina farms 15 min from hidden valley and 45 min from downtown this place is in a great location and will not disappoint!

Nov 10 – 17

$95 per night

Guest favorite

Home in Augusta

4.99 out of 5 average rating, 218 reviews

Katy Trail Farmhouse - 3 bd/2.5 bath - Amazing!

DIRECTLY ON THE KATY TRAIL! Quaint 1943 farmhouse on 7 private acres in Missouri wine country - halfway between Klondike Park & the town of Augusta. Loads of farmhouse charm w/ the amenities & comforts of home. Spacious & well-appointed, 3 bedrms/2.5 baths. Walk-in/out or bike-in/out to KATY trail -- the location is perfect. Enjoy a sunset dinner & live music at one of the many wineries – or relax on one of the two screened-in porches & clear your mind. No other place like it in Augusta!

Oct 6 – 13

$152 per night

Guest favorite

Home in Saint Charles

4.98 out of 5 average rating, 489 reviews

301 Guesthouse SuperHost/Shop Discounts/Katy Trail

Our 301 Guest House is new and completely remodeled in 2018! It’s ideal for one or two people with beautiful furnishings, great queen bed, lots of amenities, full kitchen, with big back yard and patio to enjoy outdoors too! Cable and FAST WiFi! Enjoy light Breakfast! BEST location, Great events year round within walking distance, with being only about 2 blocks from S. Main St, where there are about 100 gift shops n restaurants! Katy Trail is so close, with Spring, Summer, Fall and Xmas events!

Jan 20 – 27

$100 per night

Guest favorite

Cabin in Innsbrook

4.94 out of 5 average rating, 159 reviews

Squirrel Run at Innsbrook Resort

WINTER ---> NOV-MAR: 4 -wheel drive car is recommended. In heavy snow, the cabin is deep in the woods & services would not be able to plow you out immediately. NO PARTIES. We have a 8 person occupancy. This includes holidays. Squirrel Run is nestled on 3 acres in a secluded wooded setting within the Innsbrook Resort Community. This 2-bedroom, 1-bathroom home sleeps 8 and offers everything from hiking, canoeing, swimming, or lounging around the firepit. More details on IG @squirrel_run_ibk

Sep 16 – 23

$120 per night

Guest favorite

Guest suite in Saint Charles

4.95 out of 5 average rating, 296 reviews

Creekside Suite - Peaceful, Spacious, and Comfy

Enjoy your stay in a spacious walkout basement-level suite that includes bedroom, bathroom, living/dining room & patio. Bedroom has queen bed, dresser, desk & TV. Living room has futon, books, games & TV. TVs have Netflix. Suite has minifridge, microwave, toaster & coffee-maker. Eat at the dining table or sit up to the window counter to look out on the creek & woodlands behind the house. Situated in a quiet, safe neighborhood with parks & ponds. Just 8 miles from historic downtown St Charles.

Jun 8 – 15

$91 per night

Guest favorite

Cabin in Defiance

4.94 out of 5 average rating, 109 reviews

Hillside Cabin on 43 Acres w/ Private Lake & View!

Free from modern distractions, this 1-bedroom, 1-bath cabin in the heart of wine country is the perfect place to unplug and reconnect with nature! Immersed in lush woodlands, the Defiance vacation rental comes with all the amenities needed for a peaceful retreat, including a fishing lake, resident horses, and a fully equipped kitchen. Watch the sunrise over the hills from the porch swing before venturing off to Katy Trail, and later, head to Chandler Hill Vineyards located just minutes away!

Nov 13 – 20

$200 per night

Superhost

Tiny home in Pacific

4.89 out of 5 average rating, 484 reviews

Route 66 Cozy Cottage

* Fast Wifi (Spectrum) * Keypad entry (no keys to keep track of) * Private driveway by the front door for easy access to carry luggage in and out * Huge yard for dogs, kids or even adults to play * Lovely outdoor patio with plenty of comfortable seating and beautiful landscaping * For the kiddos- fun, colorful plastic dinnerware, toys, books, puzzles, and games (puzzles and games for adults too) * Essentials for your furbabies as well - treats, leashes, food & water bowls, waste bags, towels

Feb 9 – 16

$95 per night

Guest favorite

Home in Gray Summit

4.85 out of 5 average rating, 117 reviews

Sunset Mountain Privacy

You’ll be amazed at how private your 10 rooms are in this main level space within a shared property. Gorgeous countryside views, gardens & walking trails. Covered deck, full kitchen, & Laundry. 420 friendly. You can’t beat this value at any hotel! I stay in my private lover level with my 9 yr old son & fiancé. A newly built, fully insulated wall divides us. The only spaces we share are outside & the laundry room. $20/per extra person/per day. $30 pet fee-all dogs welcome. 420 friendly

Oct 16 – 23

$157 per night

Guest favorite

Farm stay in Lake Saint Louis

4.92 out of 5 average rating, 191 reviews

Updated Farmhouse 2 bd 2 acres

Updated Farm House on 2 acres,3 beds, 1 bth, this house has 2 bedroom with 3 beds, a fully equipped kitchen, living room, a full bathroom,double sinks,and laundry facilities, this house is a duplex, with 2 separate units, the upstairs is for Airbnb guest, the lower unit has a tenant, each unit has its own space and entrance. 25 minutes from the St. Louis Airport, close to the Missouri Wineries, Bush wild life area, and only 10 minutes to the Katie Trail along the Missouri River.

Feb 18 – 25

$106 per night

Guest favorite

Farm stay in Grafton

4.97 out of 5 average rating, 203 reviews

Pere Ridge Tree Escape

Welcome to Pere Ridge ! Enjoy the lovely setting of this romantic spot in nature. Pere Ridge is a custom Scandinavian inspired nature escape for two . Our elevated cabin is perched on a ridge with a deck and hot tub that is surrounded by trees. Our hope is that you disconnect from life's stresses while at Pere Ridge. Our cabin is located in "the ridge " area of Grafton and is a short drive to Grafton. It is a light filled studio cabin with modern touches .

Sep 19 – 26

$136 per night

Guest favorite

Guesthouse in Marthasville

4.96 out of 5 average rating, 221 reviews

Hazel's House by the Katy Trail

In the heart of Missouri Wine Country. Within walking distance of the Katy Trail and Lake Creek Winery. Many wineries within a 25-30 minute drive. Enjoy a weekend getaway in a 2 bed 1 bath home. Hazel's House is clean, comfortable and private overnight accommodations. We are not a bed and breakfast, no food included, but there is coffee. Please make sure the location is suitable. We are located out in the country and the internet can be spotty.

Feb 16 – 23

$99 per night

Guest favorite

Home in Dittmer

4.95 out of 5 average rating, 356 reviews

Honeymoon Suite Camp Skullbone In The Woods

Romantic quiet cozy chalet for two! Vintage décor with all the modern amenities of home. Relax inside to unwind, kick back and watch a movie, surf the web via free wi-fi, curl up with a good book, open up a board game for a friendly challenge or share a drink with that special someone. Want some fresh country air? Lace-up those hiking boots and take like Camp Skullbones. . Enjoy the stars on the intimate deck with the glow from the gas fire pit.

Sep 23 – 30

$135 per night

Vacation rentals for every style

Get the amount of space that is right for you

Popular amenities for Defiance vacation rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Stay near Defiance's top sights

August A. Busch. Memorial Conservation Area4 locals recommend

Chandler Hill Vineyards15 locals recommend

Weldon Spring Conservation Area3 locals recommend

Historic Daniel Boone Home15 locals recommend

Defiance Roadhouse3 locals recommend

Wine Country Gardens11 locals recommend

Other great vacation rentals in Defiance

Guest favorite

Guest suite in Dardenne Prairie

4.89 out of 5 average rating, 196 reviews

Treehouse Spa Suite

Sep 9 – 16

$68 per night

Guest favorite

Home in Saint Charles

4.97 out of 5 average rating, 175 reviews

Bright & Cozy Shotgun DPX 1 Block from Historic DT

Oct 8 – 15

$115 per night

Guest favorite

Home in Defiance

5.0 out of 5 average rating, 18 reviews

The Wilderness Home

Jul 8 – 15

$200 per night

Guest favorite

Home in Defiance

5.0 out of 5 average rating, 13 reviews

Venue at Defiance Farmhouse

Oct 2 – 9

$175 per night

Guest favorite

Cottage in Augusta

4.91 out of 5 average rating, 44 reviews

Romantic Augusta Cottage-Relax & get away!

Jul 13 – 20

$174 per night

Superhost

Guesthouse in Washington

4.82 out of 5 average rating, 49 reviews

Beautiful Guesthouse Sanctuary

Dec 13 – 20

$138 per night

Guest favorite

Apartment in O'Fallon

4.84 out of 5 average rating, 31 reviews

Cozy Condo in O Fallon Missouri

Nov 12 – 19

$96 per night

Guest favorite

Apartment in Moscow Mills

5.0 out of 5 average rating, 14 reviews

The Hidden Gem - Spacious apartment on 7 acres.

Jul 25 – Aug 1

$97 per night

Show all

Quick stats about vacation rentals in Defiance

Total rentals
10 properties
Local attractions
Chandler Hill Vineyards, August A. Busch. Memorial Conservation Area, and Weldon Spring Conservation Area
Popular amenities
Kitchen, Wifi, and Pool
Wifi availability
10 properties include access to wifi
Total number of reviews
560 reviews
Nightly prices starting at
$70 before taxes and fees

Vacation rentals in Defiance

Top-rated vacation rentals in Defiance

Tiny home in Pacific

Home in Augusta

Home in Saint Charles

Cabin in Innsbrook

Guest suite in Saint Charles

Cabin in Defiance

Tiny home in Pacific

Home in Gray Summit

Farm stay in Lake Saint Louis

Farm stay in Grafton

Guesthouse in Marthasville

Home in Dittmer

Vacation rentals for every style

Hotels

Unique stays

Homes

Popular amenities for Defiance vacation rentals

Stay near Defiance's top sights

Other great vacation rentals in Defiance

Guest suite in Dardenne Prairie

Home in Saint Charles

Home in Defiance

Home in Defiance

Cottage in Augusta

Guesthouse in Washington

Apartment in O'Fallon

Apartment in Moscow Mills

Quick stats about vacation rentals in Defiance

Total rentals

Local attractions

Popular amenities

Wifi availability

Total number of reviews

Nightly prices starting at

Destinations to explore