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Vacation rentals in Florence

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Florence

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost
Home in Effingham
Clean and Comfortable 3B/2B Home w/ 2-Car Garage
Peaceful and centrally located. 3 BR, 2 bath fully furnished house with 2 car garage in an established neighborhood. Great for healthcare and business professionals. MUSC Florence and McLeod Health are located within 9 miles from the property. Conveniently located between Charleston, SC and Myrtle Beach, SC and close to I-95 and I-20. A discount will be given at checkout for weekly and monthly rentals. Wifi, cable, and utilities included. Pack 'n play/high chair available upon request.
$92 per night
Superhost
Apartment in Florence
Kuker Carriage House-Sleeps 3-Downtown/Near I95&20
Kuker Carriage House was originally a barn that has been converted into apartments in the heart of the newly revitalized Florence downtown. This first floor unit was just fully renovated and is ready for you to enjoy, whether for a short overnight stop or a longer extended stay. This space is bright and open with lots of natural light and a fully enclosed private courtyard. Queen bed, twin daybed, full bath, Wifi and TV. Walkable to parks and restaurants. Just 4 miles from I95 and I20
$107 per night
Superhost
Guest suite in Florence
Private Apartment 5 Min Away From I-95 & I-20
Please come and enjoy our Guest Apartment in Florence, SC! A great stop for travelers to rest during their trips. Guests will have a private entrance to the apartment that is attached but separate from the main house, where me and my family live. Guest privacy will always be respected. One bedroom has a queen size bed, a second bedroom has a daybed. The bathroom has a tub and shower. The kitchen has a stove/oven. The apartment is cleaned and sanitized after each guest leaves. Thank you!
$89 per night

Stay near Florence's top sights

Red Bone Alley Restaurant15 locals recommend
Walmart Neighborhood Market4 locals recommend
Florence Center3 locals recommend
Tubb's Shrimp and Fish Co.9 locals recommend
The Drive In3 locals recommend
Percy & Willies3 locals recommend

Other great vacation rentals in Florence

Superhost
Cottage in Timmonsville
*Cottage Near Florence and I-95*
$104 per night
Superhost
Farm stay in Timmonsville
The Cottage at Dream Acres & Petting Zoo I-95/I-20
$124 per night
Superhost
Cottage in Darlington
Darlington Farm House Near I-95 & Florence
$97 per night
Superhost
Home in Lake City
Home Away From Home Apt 3 - A Hidden Gem
$59 per night
Superhost
Cottage in Florence
DOWNTOWN Pine Cottage
$68 per night
Superhost
Guesthouse in Florence
Midtown Retreat - Guest House in heart of Florence
$99 per night
Superhost
Condo in Florence
☑️Cozy Work Friendly Condo in Florence☑️
$75 per night
Superhost
Home in Florence
Pineapple House Historic Southern Charm Downtown
$82 per night
Superhost
Bungalow in Florence
Quaint Bungalow in Historic Downtown Florence
$98 per night
Superhost
Apartment in Florence
Modern 3B/2Ba Condo- Sleeps 6, near Civic Center
$159 per night
Superhost
Apartment in Florence
Beautiful two bedroom getaway
$107 per night
Superhost
Condo in Florence
Modern 1 bedroom condo near downtown Florence
$80 per night