Vacation rentals in Greenville

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Greenville

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost

Home in Salem

4.89 out of 5 average rating, 272 reviews

Beaver Lake House-Welcome to Social Distance Land!

Unique remote location on family farm. A secluded stone house with 50 ' deck overlooking Beaver Lake. Watch & hear amazing wildlife! Open kitchen, dining/living room, woodstove, tile floors 2 bedrooms; larger with queen, smaller 2 twin beds, 2 sofa beds in living room. 2 new bathrooms, laundry room, picnic table, BBQ, access to Sinking creek, 9 acre lake to fish & 400 acre farm to explore! For additional accommodation check out The Mushroom Loft House across the creek also available on Airbnb.

Dec 11 – 18

$120 per night
Guest favorite

Home in Fredericktown

4.94 out of 5 average rating, 179 reviews

Outdoor Heart BathTub The Rustic Rose River Access

The Rustic Rose is one of 7 uniquely themed stays on our small private family ran campground. It’s a short 5 minute walk through the property trails to crystal clear river -12Mile Creek just south of Fredericktown, MO. You will have 33 acres to explore, with refreshing swimming holes, shut-ins, bluffs, fishing, wooded trails and more than enough nature to bask in. Deer, rabbits, turtles & many different species of birds too! The unique old Vegas style, whimsical décor makes for a memorable stay!

Dec 5 – 12

$133 per night
Guest favorite

Treehouse in Greenville

5.0 out of 5 average rating, 137 reviews

NEW treehouse B&B for 2 "The Roost” with hot tub

Cozy new 2022 custom built rustic but not primitive cabin 2 hours south of St Louis MO. Yes it has indoor plumbing and running water. Accommodates two adults only, has a fully equipped kitchen and breakfast items are provided for you to cook. Surrounded by thousands of acres of national forest. Observe wildlife sightings from the deck while soaking in the hot tub, sleep comfortably in a queen size pillowtop Serta bed on a Motion Air base, and relax as you enjoy the ambience of the fireplace.

Jan 10 – 17

$152 per night

Popular amenities for Greenville vacation rentals

Other great vacation rentals in Greenville

Guest favorite

Cabin in Black River Township

4.98 out of 5 average rating, 49 reviews

Well-Designed Cozy Cabin near lake and hiking

Oct 15 – 22

$102 per night
Guest favorite

Cabin in Piedmont

5.0 out of 5 average rating, 22 reviews

BaseCamp Cabin near Clearwater Lake/ Black River

Nov 17 – 24

$160 per night
Guest favorite

Home in Poplar Bluff

4.98 out of 5 average rating, 48 reviews

Little Blue

Mar 9 – 16

$131 per night
Guest favorite

Tiny home in Annapolis

4.94 out of 5 average rating, 36 reviews

Charming cabin on the creek

Mar 4 – 11

$72 per night
Guest favorite

Cabin in Patterson

5.0 out of 5 average rating, 23 reviews

Lakeview Cabin w/ hot tub

Aug 16 – 23

$152 per night
Guest favorite

Cabin in Wappapello

4.93 out of 5 average rating, 14 reviews

*HOT TUB* Camp Minnow-Beach House

Oct 8 – 15

$131 per night
Guest favorite

Home in Bloomfield

5.0 out of 5 average rating, 12 reviews

Bloomfield Bungalow

Oct 14 – 21

$99 per night
Guest favorite

Cottage in Marquand

4.86 out of 5 average rating, 44 reviews

Country Retreat

Apr 30 – May 7

$113 per night
Guest favorite

Cottage in Wappapello

4.9 out of 5 average rating, 30 reviews

Ridge Road Casita

Feb 16 – 23

$125 per night
Guest favorite

Home in Piedmont

4.95 out of 5 average rating, 21 reviews

Clearwater Lake Red Roof Cabin

May 2 – 9

$135 per night
Superhost

Tiny home in Zalma

5.0 out of 5 average rating, 10 reviews

Moe and Daves hunting shack!

Aug 1 – 8

$85 per night
Guest favorite

Home in Puxico

4.9 out of 5 average rating, 29 reviews

Historic Binford Home in Downtown Puxico

Jun 2 – 9

$110 per night

Destinations to explore

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  5. Greenville