House vacation rentals in Oconee County

Find and book unique houses on Airbnb

Top-rated house rentals in Oconee County

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in West Union

4.95 out of 5 average rating, 137 reviews

Sunsets and Siestas -Lake Keowee home near Clemson

Sunsets and Siestas - A beautiful Lake Keowee waterfront home, near Clemson, SC. Make our lovely 3700 sq ft lake house on Lake Keowee your home away from home! Perfect for family gatherings, retreats, and more. We can comfortably sleep up to 16 people and with three separate sitting rooms, there's ample space for games and conversation. Enjoy a day on the lake boating, and swimming, relax in our hot tub or our private front yard pool, or venture out and explore beautiful upstate South Carolina.

Mar 22 – 29

$366 per night

Guest favorite

Home in Townville

4.94 out of 5 average rating, 150 reviews

Zoey’s Cottage on Lake Hartwell w/dock- Secluded

This cozy charming and quiet lake property is the perfect getaway for families & friends . Located 5 minutes off I-85 and is 10 minutes to Green pond Landing, 20 minutes to Clemson, Anderson and Seneca. Perfect place to enjoy fishing, shopping and Clemson football games, Enjoy using the back porch to view the sunrise over lake Hartwell and the wildlife as it pass through. The porch is a nice relaxing cozy place where you can enjoy your coffee or a glass of wine while watching the lake glisten.

May 22 – 29

$293 per night

Guest favorite

Home in Westminster

4.94 out of 5 average rating, 254 reviews

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Mar 3 – 10

$404 per night

Guest favorite

Home in Seneca

4.95 out of 5 average rating, 143 reviews

Private lake setting close to Clemson University

House is located in a private community yet only 2.5 miles to Death Valley and Clemson. Enjoy a walk down to the lake or relax on the back deck. WIFI is included with access to Hulu and Disney+. Kid friendly as well. Property is also within 1.2 miles of Oconee Airport, 0.7 miles to a dock, 1.5 miles to the grocery store, and less than 1.3 miles to Y beach public parking (avoid game day traffic if you are coming in for football). Close to everything in Oconee, Pickens and Anderson Counties.

Dec 7 – 14

$126 per night

Guest favorite

Home in Six Mile

4.87 out of 5 average rating, 195 reviews

House on Lake Keowee swim beach in cove w/ Dock

This two story home is located at the end of a very quiet cove with plenty of water. The beach has a fresh 6 inches of sand installed for the lake season. The walk to the lake is very short on an almost flat surface. The home will accommodate a family up to six people. The house has two floors. The main floor has a large living room with plenty of comfortable seating and satellite TV service provided. The entire main floor has hard woods along with the Master Bed Room and bed room #2.

Jan 1 – 8

$255 per night

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 168 reviews

Lakeside @ Lake Hartwell in Clemson, SC 🐟🌅🚤

Lake lovers and college football fans...you will LOVE this house! Lots of privacy, huge kitchen, dock, fire pit, gas grill, kayaks, and more! Beautiful Lake Hartwell home… where 1000 miles of shore awaits you! Our home is located just minutes away from Clemson, Seneca, Anderson, and more! Just 25 steps to your private dock, and 7 miles/ 10 mins from Death Valley (Memorial Stadium!) 4 bedrooms, and 3 full bathrooms. You must be at least 25 to rent. NO pets allowed, sorry!No fireworks

Sep 30 – Oct 7

$382 per night

Guest favorite

Home in Toccoa

4.97 out of 5 average rating, 144 reviews

Inn The Cove Lake House

Welcome to Inn the Cove--a meticulously renovated, luxury Lake Hartwell escape. Nestled into a cul-de-sac, there is plenty of room to sprawl with a massive deck, cozy screened porch, detached games room "The Boathouse" & generous living space. There is a brand new dock with large covered area, 4 boats at your disposal (1 double & 2 single kayaks & a paddle boat) & room to tie up your own boat. Enjoy the lake by day & the pool table or firepit by night. Have a blast & unwind #InnTheCove!

Nov 8 – 15

$221 per night

Guest favorite

Home in Salem

4.85 out of 5 average rating, 108 reviews

Mountains and Lake Area

Come stay at our cozy house. It has a full kitchen . Enjoy your private deck that has a shade tree. Comfy beds and sitting area. Car shed for two and plenty of room for a boat. The neighborhood is very safe and friendly. They respect your privacy. There are 3 boat ramps within 3-7 miles to access Lake Keowee. Lake Jocassee , Devils Fork State Park, is 10 miles. They have a boat ramp and boat and kayak rentals. The Flat Shoals river is just 3 miles away. Come have some fun in Salem!

Jul 30 – Aug 6

$113 per night

Guest favorite

Home in Westminster

5.0 out of 5 average rating, 18 reviews

The Hilltop Hideaway at Lake Hartwell

Perched atop a secluded hill, this unique treehouse offers stunning mountain and nature views. A one-of-a-kind getaway with ample outdoor space, it features a master bedroom with expansive windows for stargazing. Sleep comfortably with a king bed, bunk beds, and a queen sofa. Enjoy WiFi, heated bathroom floors, & free Tesla EV charging. The clubhouse boasts an Olympic pool, snack bar, restaurant & bar for the complete retreat experience.

Aug 26 – Sep 2

$112 per night

Guest favorite

Home in Westminster

4.92 out of 5 average rating, 88 reviews

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Oct 14 – 21

$105 per night

Guest favorite

Home in Seneca

4.99 out of 5 average rating, 173 reviews

The Cozy Cottage

Beautiful, well-maintained home located in a private subdivision just minutes away from shopping, restaurants, lakes, golf courses, and Clemson University. This home has a fully equipped kitchen for dining in and a back patio for grilling out. Perfect for getaways, football weekends, graduation, and other Clemson University events! *NO SMOKING OR VAPING ALLOWED INSIDE THE HOUSE OR ON THE PROPERTY

Feb 2 – 9

$158 per night

Guest favorite

Home in Six Mile

4.96 out of 5 average rating, 26 reviews

3 BR House Near Clemson

CONVENIENT LOCATION Situated just 10 minutes from Lake Keowee and 20 minutes from Seneca or Clemson. Enjoy tranquility and privacy slightly off the beaten path. Surrounded by lush trees and boasting a spacious yard that's all yours, this haven offers a sense of seclusion and peace. This house is the perfect location for relaxation and convenience.

Jul 7 – 14

$105 per night