Vacation rentals in Santee River
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Top-rated vacation rentals in Santee River
Guests agree: these stays are highly rated for location, cleanliness, and more.
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Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Santee River vacation rentals
Other great vacation rentals in Santee River
Guest favorite
Home in Moncks Corner
4.97 out of 5 average rating, 63 reviewsLake Living
Oct 16 – 23
$113 per night
Guest favorite
Home in Bonneau
5.0 out of 5 average rating, 6 reviewsLake House Retreat - Pet Friendly - Private Dock
Aug 18 – 25
$245 per night
Guest favorite
Apartment in Moncks Corner
4.91 out of 5 average rating, 54 reviewsJay’s Upstairs Suite
Jan 8 – 15
$58 per night
Guest favorite
Home in Manning
4.9 out of 5 average rating, 21 reviewsCozy Church Branch Cabin
Oct 22 – 29
$94 per night
Superhost
Tiny home in Cross
5.0 out of 5 average rating, 12 reviewsTiny Cabin W/ Lake Moultrie View
Dec 22 – 29
$80 per night
Guest favorite
Cottage in Hemingway
4.98 out of 5 average rating, 66 reviewsCountry Cottage at Black Mingo Plantation
Dec 31 – Jan 7
$104 per night
Guest favorite
Guest suite in Moncks Corner
4.94 out of 5 average rating, 51 reviewsPeaceful Pimlico Paradise by the River
Nov 10 – 17
$118 per night
Guest favorite
Home in Summerville
4.97 out of 5 average rating, 31 reviewsGuest House/Villa
Aug 12 – 19
$91 per night
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