House vacation rentals in South Carolina

Find and book unique houses on Airbnb

Top-rated house rentals in South Carolina

Guests agree: these houses are highly rated for location, cleanliness, and more.

Guest favorite
Home in Rock Hill
1800s Cabin on Holland Acres - Getaway or gather
Step back in time in a 1800s roadside cabin on four acres. Grill on the back deck, relax in the hot tub, soak in the claw foot tub and simply enjoy the serenity. Cabin has a full kitchen, two baths, and main floor & loft sleeping areas. You'll be minutes from downtown Rock Hill and the Event Center, restaurants, parks, & Winthrop Univ. Rural setting makes a perfect families & pets getaway; unique features make it great for gathering! Come enjoy this quaint piece of history & prepare to unwind!
Apr 29 – May 6
$112 per night
4.93 out of 5 average rating, 186 reviews
Guest favorite
Home in Westminster
Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.
Jun 9 – 16
$381 per night
4.94 out of 5 average rating, 252 reviews
Guest favorite
Home in Easley
“Lake House Paradise” Waterfront Oasis
“Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views from your bed of the water. Your en suite Master Bathroom has a large luxury marble shower. You will spend many hours of relaxation and peace in the most desirable location in the southeast. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.
Feb 25 – Mar 4
$125 per night
4.9 out of 5 average rating, 266 reviews

Popular amenities for South Carolina house rentals

House rentals with a pool

Guest favorite
Home in Folly Beach
Luxury Beach Living With Heated Pool
Dec 14 – 21
$610 per night
4.97 out of 5 average rating, 143 reviews
Guest favorite
Home in Summerton
Luxurious Lakefront Log Home W/Pool & hot tub
Sep 16 – 23
$553 per night
4.97 out of 5 average rating, 102 reviews
Guest favorite
Home in Myrtle Beach
Private Beach Paradise in Ocean Lakes w/ Golf Cart
Jan 30 – Feb 6
$160 per night
4.92 out of 5 average rating, 180 reviews
Superhost
Home in Myrtle Beach
Comfortable Cottage One Block To Beach!
Nov 14 – 21
$86 per night
4.88 out of 5 average rating, 309 reviews
Guest favorite
Home in North Myrtle Beach
Luxury Ocean View - Private Pool/Jacuzzi, Elevator
Feb 7 – 14
$473 per night
4.99 out of 5 average rating, 100 reviews
Guest favorite
Home in Saint Helena Island
The Hampton House
Nov 4 – 11
$725 per night
4.99 out of 5 average rating, 104 reviews
Guest favorite
Home in Hilton Head Island
Lovely 3BR in Palmetto Dunes w/ new pool & spa
Feb 3 – 10
$429 per night
4.97 out of 5 average rating, 105 reviews
Guest favorite
Home in North Myrtle Beach
Luxury Cayman Villa in Caribbean Style Resort
Mar 13 – 20
$262 per night
4.97 out of 5 average rating, 105 reviews
Guest favorite
Home in Hilton Head Island
Coastal Town Gallery House - live like a local!
Dec 19 – 26
$354 per night
4.85 out of 5 average rating, 198 reviews
Guest favorite
Home in North Myrtle Beach
Oceanview 4/2, XL pool/hot tub, steps to beach!
Feb 20 – 27
$99 per night
4.93 out of 5 average rating, 123 reviews
Guest favorite
Home in Seabrook Island
Brand New Island Getaway
Oct 11 – 18
$435 per night
4.98 out of 5 average rating, 107 reviews
Guest favorite
Home in Aiken
French Tudor in Quiet Aiken County
Sep 27 – Oct 4
$283 per night
4.99 out of 5 average rating, 119 reviews

House rentals with free parking

Guest favorite
Home in Murrells Inlet
Southern Charm Cottage with Screened Porch & Golf Cart
Aug 27 – Sep 3
$315 per night
4.97 out of 5 average rating, 296 reviews
Guest favorite
Home in Lexington
Lakefront home on Lake Murray with private dock
Jul 8 – 15
$484 per night
4.97 out of 5 average rating, 123 reviews
Guest favorite
Home in Iva
Country Cottage ~ Farm Animals!
Mar 9 – 16
$72 per night
4.98 out of 5 average rating, 343 reviews
Guest favorite
Home in Abbeville
**Oak View**Peaceful**8 min to Erskine
Jul 6 – 13
$63 per night
4.99 out of 5 average rating, 216 reviews
Guest favorite
Home in Folly Beach
Pelican's Porch on Folly Beach-Oceanview
May 18 – 23
$250 per night
4.91 out of 5 average rating, 237 reviews
Guest favorite
Home in Santee
Santee lakefront home, big water right off I-95
Nov 22 – 29
$476 per night
4.97 out of 5 average rating, 136 reviews
Guest favorite
Home in Summerville
Schoolhouse Cottage in Historic Summerville
Dec 4 – 11
$96 per night
4.97 out of 5 average rating, 247 reviews
Guest favorite
Home in Charleston
Historic Kitchen House - South of Broad (Charming)
Jul 3 – 10
$599 per night
4.96 out of 5 average rating, 138 reviews
Guest favorite
Home in North Myrtle Beach
Pineapple Express
Feb 12 – 19
$130 per night
4.85 out of 5 average rating, 194 reviews
Guest favorite
Home in Folly Beach
Steps 2 BEACH * *bright and airy cottage **
Sep 25 – Oct 2
$291 per night
4.86 out of 5 average rating, 205 reviews
Guest favorite
Home in Charleston
Perfect 1-Bedroom Guest Suite - Great Amenities!
Sep 16 – 23
$95 per night
5.0 out of 5 average rating, 110 reviews
Guest favorite
Home in Chappells
Greenwood Lake Front, FirePit, Outside Kitch, Dock
Feb 12 – 19
$269 per night
4.95 out of 5 average rating, 142 reviews

House rentals with a hot tub

Guest favorite
Home in Inman
LakingitEz..3BR/2BA amazing sunsets & hot tub
Oct 28 – Nov 4
$248 per night
4.93 out of 5 average rating, 224 reviews
Guest favorite
Home in Easley
Spectacular Lakefront Retreat on the Saluda
Dec 12 – 19
$200 per night
4.91 out of 5 average rating, 175 reviews
Guest favorite
Home in Isle of Palms
Intracoastal water view luxurious family retreat
Nov 8 – 15
$655 per night
4.96 out of 5 average rating, 123 reviews
Guest favorite
Home in North Myrtle Beach
Luxury Villa in Caribbean-Style Beach Resort
Oct 31 – Nov 7
$248 per night
4.93 out of 5 average rating, 149 reviews
Guest favorite
Home in Modoc
Ivy’s Escape (water front) at Lake Thurmond
May 5 – 12
$293 per night
4.95 out of 5 average rating, 100 reviews
Guest favorite
Home in Charleston
Best of Both Worlds with Beautiful Back-Yard Oasis
Jan 27 – Feb 3
$125 per night
4.84 out of 5 average rating, 425 reviews
Guest favorite
Home in North Charleston
Wheelchair access, King bed, hot tub upon request
Aug 7 – 14
$149 per night
4.88 out of 5 average rating, 140 reviews
Superhost
Home in Beaufort
Estate Living on 5 acres with pool in Beaufort, SC
Jan 7 – 14
$314 per night
4.89 out of 5 average rating, 143 reviews
Guest favorite
Home in Charleston
Waterfront Home 5 minutes From Downtown Charleston
Jul 16 – 23
$552 per night
4.81 out of 5 average rating, 288 reviews
Guest favorite
Home in Lexington
Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.
Sep 12 – 19
$214 per night
4.87 out of 5 average rating, 139 reviews
Guest favorite
Home in North Myrtle Beach
LuxuryNorthBeachHome,Pool,Elevator,Marsh/OceanView
Apr 28 – May 5
$473 per night
4.98 out of 5 average rating, 113 reviews
Guest favorite
Home in Mount Pleasant
Pleasant Place: Newly Built with Pool: Close to downtown/beach
Nov 5 – 12
$805 per night
4.95 out of 5 average rating, 101 reviews

Destinations to explore