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Villa vacation rentals in South Carolina

Find and book unique villas on Airbnb

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Top-rated villa rentals in South Carolina

Guests agree: these villas are highly rated for location, cleanliness, and more.

Guest favorite
Villa in kiawah island
Kiawah Villa 2 Bed/2 Bath
Kiawah Island - 2 Bedroom / 2 full baths inTennis club villa. Extra sleeping with sofa bed. Dog (2) friendly. 10 minute walk to beach. Close to Sanctuary hotel and Roy Barth tennis. High speed internet and desk. Fully furnished -all that you need. high end linens, upgraded beds, beach chairs and fully stocked kitchen. Enjoy coffee on screened in porch. Access to resort golf or tennis and restaurants. Book activities reservations early. Sorry-there is no pool access.
Jan 12 – 19
$245 per night
Guest favorite
Villa in Johns Island
Renovated Kiawah Villa Steps to Beach
Welcome to Mimosa Manor, a completely renovated 1 bedroom/ 1 Bath villa just steps to beautiful East Beach on Kiawah Island. Villa sleeps four comfortably with king master suite AND queen size Murphy bed. Mimosa Manor is a first floor villa in the Mariner's Watch Complex (within the gates on Kiawah Island) with a gorgeous wooded view and is just a 35-minute drive from the cobblestone clad streets of downtown Charleston. Business License Number: RBL20-000419
Dec 30 – Jan 6
$202 per night
Guest favorite
Villa in Johns Island
Updated beach getaway with amazing lagoon views
Newly renovated. Clean and fresh beach decor. 950 sq ft "treehouse" on beautiful Seabrook Island with lots of extras. Huge floor to ceiling doors and windows that overlook a beautiful lagoon with wildlife galore. Gaze outside for hours and view amazing birds, deer, fish, turtles, and even an alligator or two! Large deck with seating for six and a grill. WiFi and three smart tvs. Seabrook Island Business License # 20191576 MAXIMUM 2 VEHICLES
Aug 21 – 28
$230 per night

Popular amenities for South Carolina villa rentals

Villa rentals with a pool

Superhost
Villa in Hilton Head Island
Coastal Charm - Beach, pickleball, golf, pets
Apr 30 – May 7
$272 per night
Guest favorite
Villa in Hilton Head Island
Spacious Villa with Two King Suites
Jun 5 – 12
$456 per night
Guest favorite
Villa in Hilton Head Island
COMPLETELY REMODELED 3 BR Great Location
Dec 28 – Jan 4
$257 per night
Guest favorite
Villa in Seabrook Island
Beautifully Transformed Upper Level Deluxe Villa
Nov 19 – 26
$150 per night
Guest favorite
Villa in Saint Helena Island
Little Palm Villa | Oceanfront
Dec 6 – 13
$304 per night
Guest favorite
Villa in Hilton Head Island
Oceanfront Scandi Oasis Amazing View & Heated Pool
May 14 – 21
$375 per night
Guest favorite
Villa in Seabrook Island
Private island villa with luxury resort amenities!
Aug 13 – 20
$177 per night
Guest favorite
Villa in Hilton Head Island
Direct beach access for couple’s getaway!
Nov 23 – 30
$140 per night
Guest favorite
Villa in Isle of Palms
Port O' Call B103 - Oceanfront Oasis! Walkout!
Jan 9 – 16
$383 per night
Guest favorite
Villa in Hilton Head Island
Windsor Place Villa 102
Sep 18 – 25
$178 per night
Guest favorite
Villa in Seabrook Island
Great Rates! Screen Porch! Pool!
Jul 25 – Aug 1
$121 per night
Guest favorite
Villa in Hilton Head Island
Best Location-Shipyard, Walk to Beach, Updated,
May 4 – 11
$187 per night

Villa rentals with a hot tub

Guest favorite
Villa in Hilton Head Island
Gorgeous Waterfront Shelter Cove Condo.
Nov 25 – Dec 2
$191 per night
Guest favorite
Villa in Isle of Palms
The Heart of Isle of Palms - Wild Dunes
Feb 11 – 18
$411 per night
Guest favorite
Villa in Hilton Head Island
Newly updated Crown Reef Villa. Walk to beach!
Jun 9 – 16
$420 per night
Guest favorite
Villa in Hilton Head Island
Walk to the Beach, Indoor Pool, King Bed, Hot Tub!
Jun 6 – 13
$383 per night
Guest favorite
Villa in Hilton Head Island
3BR Ocean Palm Villa. View over the 8th hole!
Aug 18 – 25
$261 per night
Superhost
Villa in Hilton Head Island
Beach, Golf, Tennis, Lovely Villa
Feb 8 – 15
$145 per night
Superhost
Villa in Hilton Head Island
Beautiful first floor Villa peaceful wildlife view
May 8 – 15
$186 per night
Guest favorite
Villa in Myrtle Beach
Beautiful 2 Bedroom Garden Home in Ocean Creek
Feb 2 – 9
$250 per night
Superhost
Villa in Hilton Head Island
1501 Island Club - Folly Field - 2 Bed 2 Bath Slee
Dec 19 – 26
$222 per night
Superhost
Villa in Hilton Head Island
Ocean Views | Complimentary Activities
Mar 11 – 18
$186 per night
Superhost
Villa in Hilton Head Island
Beachfront Bliss, Oceanfront Villa, Pool, Hot Tub
Feb 12 – 19
$542 per night
Superhost
Villa in Hilton Head Island
Ocean Palms Villa: Discounted Golf & Westin Access
Dec 28 – Jan 4
$225 per night

Private villa rentals

Guest favorite
Villa in Mount Pleasant
Beach Chic Coastal Villa! Walk to restaurants.
Jun 7 – 14
$250 per night
Guest favorite
Villa in Kiawah Island
New reno, Boho-style "treehouse" at the beach!
Nov 13 – 20
$147 per night
Guest favorite
Villa in Kiawah Island
Spacious new 2BR Villa across beach near Sanctuary
Jul 19 – 26
$625 per night
Guest favorite
Villa in Hilton Head Island
51 Ocean Club - host2coast
Jan 2 – 9
$276 per night
Guest favorite
Villa in Saint Helena Island
Sandy Toes Condos
Nov 18 – 25
$180 per night
Guest favorite
Villa in Kiawah Island
Lagoon view villa with office, easy walk to beach!
Nov 30 – Dec 7
$186 per night
Superhost
Villa in Hilton Head Island
Spacious dog-friendly villa, walk to the beach
Jul 7 – 14
$368 per night
Guest favorite
Villa in Hilton Head Island
Beautifully Renovated 2 bed/2bath - Walk to Beach
Dec 29 – Jan 5
$292 per night
Guest favorite
Villa in Myrtle Beach
Spacious 4-Bedroom Tupelo Bay Golf Resort Villa
May 28 – Jun 4
$397 per night
Guest favorite
Villa in Hilton Head Island
Newly Renovated w/Golf views. Walk to Beach & Pool
Aug 3 – 10
$350 per night
Superhost
Villa in Saint Helena Island
Water Views Short Walk to Dataw Clubhouse and Pool
May 10 – 17
$285 per night
Guest favorite
Villa in Isle of Palms
Luxury Isle of Palms Home Steps to Beach with Pool
Jan 18 – 25
$616 per night

Destinations to explore