Cape Girardeau vacation rentals

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Top-rated vacation rentals in Cape Girardeau

Guests agree: these vacation rentals are highly rated for location, cleanliness, and more.

Guest favorite
Apartment in Cape Girardeau
Beautiful Historic Boulevard District Apartment
This beautiful, private upstairs apartment is located on a favorite street in Cape Girardeau’s Historic Boulevard District. It is walking distance to SEMO University, Capaha Park, and the downtown riverfront. Recently remodeled for laundry, spacious rooms offer private bedroom spaces and a cozy den for watching movies or reading. The kitchen is fully equipped with amenities. This quiet neighborhood setting even has a front porch swing and sitting area where you can enjoy your morning coffee.
Apr 21 – 28
$85 per night
4.97 out of 5 average rating, 340 reviews
Guest favorite
Guest suite in Cape Girardeau
MAINSTAY CAPE [downtown]
Nestled in the heart of the Downtown Historic District, this suite is centrally located as a prime destination for any and all travelers alike. With parking available, this space offers a unique & trendy “midwest boho” vibe. ~WALKABLE~ Our studio is 1 block from the bustling Southeast Missouri State University, 1 block from the gorgeous Capaha Park, and 2 blocks from Mercy Hospital. If you are interested in night life, this space is simply a 5-10 minute walk to all DT bars and restaurants.
Apr 21 – 28
$69 per night
4.96 out of 5 average rating, 104 reviews
Guest favorite
Apartment in Cape Girardeau
Brand new 2 bedroom unit right in downtown Cape.
This special place is close to everything, making it easy to plan your visit. Walking distance to restaurants, the river and nightlife. Property includes wifi, full kitchen, laundry, deck and private parking for one. One king bed room and a twin bed room in addition to a roll out twin bed along with a 60 inch smart television. Dog bed and bowls included along with board games! Property is conveniently located across the street from "The Bar" the famous spot from the movie "Gone Girl" .
Oct 2 – 9
$108 per night
4.94 out of 5 average rating, 163 reviews

Popular amenities for Cape Girardeau vacation rentals

Stay near Cape Girardeau's top sights

Capaha Park4 locals recommend
Dogwood Social House3 locals recommend
Port Cape13 locals recommend
Katy O'Ferrell's Publick House9 locals recommend
Mary Jane bourbon + smokehouse7 locals recommend
Pilot House Restaurant & Catering3 locals recommend

Other great vacation rentals in Cape Girardeau

Guest favorite
Cottage in Cape Girardeau
Historic Cottage Walkable to Downtown Cape
Jun 13 – 20
$146 per night
4.98 out of 5 average rating, 170 reviews
Guest favorite
Home in Jackson
(:Convenience is Key
Sep 13 – 20
$97 per night
4.82 out of 5 average rating, 176 reviews
Guest favorite
Home in Cape Girardeau
The Hamilton House
Apr 28 – May 5
$92 per night
4.98 out of 5 average rating, 343 reviews
Guest favorite
Home in Cape Girardeau
River Run
Jan 4 – 11
$208 per night
4.97 out of 5 average rating, 116 reviews
Guest favorite
Home in Jackson
The Rusty Owl-A Charming Victorian Dwelling
Mar 29 – Apr 5
$96 per night
4.92 out of 5 average rating, 260 reviews
Guest favorite
Loft in Perryville
June Bug’s Loft **NO CLEANING FEE**
Jul 12 – 19
$72 per night
4.92 out of 5 average rating, 334 reviews
Guest favorite
Place to stay in Cobden
Eva's Roost Retreat - Center For Lost Arts
Jun 25 – Jul 2
$96 per night
4.95 out of 5 average rating, 266 reviews
Guest favorite
Cabin in Alto Pass
Hutchins Creek Cabin -2br- Wine Trail & Wilderness
May 15 – 22
$120 per night
4.92 out of 5 average rating, 132 reviews
Guest favorite
Guesthouse in Carbondale
Homestead Cottage
Jul 28 – Aug 4
$73 per night
5.0 out of 5 average rating, 165 reviews
Guest favorite
Treehouse in Makanda
Panthers Inn Treehouse
Jul 31 – Aug 7
$136 per night
4.98 out of 5 average rating, 163 reviews
Guest favorite
Guest suite in Perryville
Tranquil Retreat! Serene, Spacious Guest Suite!
Mar 30 – Apr 6
$102 per night
4.95 out of 5 average rating, 287 reviews
Guest favorite
Treehouse in Cape Girardeau
Twisted Sassafras Treehouse
Nov 25 – Dec 2
$213 per night
4.98 out of 5 average rating, 48 reviews

Other great vacation rentals in Cape Girardeau

Guest favorite
Cottage in Cape Girardeau
Country cottage with view of winding creek
May 24 – 31
$114 per night
4.9 out of 5 average rating, 72 reviews
Guest favorite
Tiny home in Jackson
The Cottage, Rusted Route Farms
Mar 30 – Apr 6
$139 per night
5.0 out of 5 average rating, 13 reviews
Guest favorite
Apartment in Cape Girardeau
Gail's Corner Window- River View
Apr 23 – 30
$121 per night
4.84 out of 5 average rating, 19 reviews
Guest favorite
Apartment in Cape Girardeau
Private Downtown Apartment
Dec 13 – 20
$110 per night
4.97 out of 5 average rating, 58 reviews
Guest favorite
Apartment in Cape Girardeau
Historical Kage House
May 17 – 24
$134 per night
4.97 out of 5 average rating, 70 reviews
Superhost
Home in Cape Girardeau
Herman’s Cozy Corner
Nov 18 – 25
$68 per night
4.83 out of 5 average rating, 63 reviews
Guest favorite
Home in Cape Girardeau
Cozy Cottage
Jul 19 – 26
$114 per night
4.94 out of 5 average rating, 34 reviews
Guest favorite
Loft in Cape Girardeau
Lorimier Loft Gallery next to SEMO River Campus
Oct 16 – 23
$137 per night
5.0 out of 5 average rating, 11 reviews
Guest favorite
Cottage in Cape Girardeau
Beautiful Sunset Cottage with amazing views
Feb 14 – 21
$364 per night
5.0 out of 5 average rating, 19 reviews
Guest favorite
Guesthouse in Jackson
Guesthouse w/ pool, outdoor fireplace, game room
Apr 14 – 21
$236 per night
5.0 out of 5 average rating, 22 reviews
Guest favorite
Home in Cape Girardeau
SEMO Redhawks Campus Home with Hot Tub
Aug 15 – 22
$249 per night
4.82 out of 5 average rating, 11 reviews
Guest favorite
Home in Oran
The Blue Door
Jan 12 – 19
$81 per night
4.89 out of 5 average rating, 47 reviews

Quick stats about vacation rentals in Cape Girardeau

Total rentals

140 properties

Rentals with dedicated workspaces

90 properties have a dedicated workspace

Pet-friendly rentals

40 properties allow pets

Family-friendly rentals

60 properties are a good fit for families

Total number of reviews

8K reviews

Nightly prices starting at

$20 before taxes and fees

Destinations to explore