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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost
Apartment in Puerto Ayora
Cute and bright two-level apartment!
This recently renovated two level apartment has its own private entrance, accessed via a quiet street. Downstairs there is a small patio and garden, inside is the living room with a small work space, the bedroom with king sized bed and AC, and an ensuite bathroom. Upstairs is a fully equipped bright kitchen with an eat in breakfast bar. Attached to the kitchen is balcony with an outdoor dining area and views of the garden.
$69 per night
Superhost
Villa in Santa Cruz
Secluded Wooden Cabin with Stunning Ocean Views
Gaze into the endless pacific ocean from this exclusive wooden cabin set in the middle of a fruit farm on the sunny east side of Santa Cruz Island, a 20 minute drive from Puerto Ayora. Here you will have the whole property to yourself and be able to relax in the middle of nature with complete privacy, super fast starlink internet and the opportunity to see endemic animals and wildlife up-close just outside the doorstep.
$169 per night
Superhost
Apartment in Puerto Ayora
Galapagos studio "Encantadas" Sea
Beautiful bright apartment in a quiet neighborhood. Full equipped. 5 minutes’ walk to the trail to Tortuga Bay and a 5 min walk from the town center. 8 years of experience with Airbnb, 16 years in the tourism business, and hundreds of positive reviews are our best business cards! If you are traveling more than two people, we also have “Galapagos Studio Encantadas Ocean.” We are certified by the Ministry of Tourism
$77 per night

Other great vacation rentals in Santa Cruz

Superhost
Apartment in Puerto Ayora
Galapagos Sol Marina Garden Loft
$65 per night
Superhost
Apartment in Puerto Ayora
Modern and spacious apartment in prime location
$97 per night
Superhost
Apartment in Puerto Ayora
Oceanview Suite: Casa Nido
$102 per night
Superhost
Treehouse in Puerto Ayora
Cozy bamboo cottage
$43 per night
Superhost
Apartment in Puerto Ayora
Suite has access to the terrace overlooking the Bay.
$50 per night
Superhost
Apartment in Puerto Ayora
Bright and cozy 2 bedroom home away from home
$136 per night
Superhost
Townhouse in Puerto Ayora
It rents a spacious duplex.
$40 per night
Superhost
Apartment in Puerto Ayora
Island Life Studio Galapagos
$108 per night
Superhost
Guest suite in Puerto Ayora
Nice suite in Puerto Ayora, Galapagos
$45 per night
Superhost
Guesthouse in Puerto Ayora
Darwin's Suite Tortuga Bay - great location
$55 per night
Superhost
Home in Puerto Ayora
The Cactus house
$75 per night
Superhost
Vacation home in Puerto Ayora
Brand new apartment in the heart of Puerto Ayora
$170 per night

Destinations to explore