Villa vacation rentals in James Island
Find and book unique villas on Airbnb
Top-rated villa rentals in James Island
Guests agree: these villas are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for James Island villa rentals
Private villa rentals
Villa in Seabrook Island
5.0 out of 5 average rating, 14 reviewsClose to beach, pools, tennis& golf+Amenity Card*
Villa in Seabrook Island
4.92 out of 5 average rating, 13 reviewsLuxury Seabrook Isl Beach Condo
Villa in Kiawah Island
4.93 out of 5 average rating, 97 reviewsClean & Comfortable! Steps to the beach!
Villa in Seabrook Island
4.83 out of 5 average rating, 59 reviewsPrivate island villa with luxury resort amenities!
Villa in Seabrook Island
4.86 out of 5 average rating, 36 reviewsSeabrook Golf View Villa: Pickleball, Bike, Pool
Villa in Seabrook Island
4.91 out of 5 average rating, 33 reviewsUpscale Villa, Amenity Included! Dog Friendly
Villa in Seabrook Island
4.93 out of 5 average rating, 55 reviewsNewly Remodeled Villa, 5 Minute Walk to Beach
Villa in Seabrook Island
4.7 out of 5 average rating, 10 reviewsBeach and Golf Paradise | Vaughan Villa
Luxury villa rentals
Villa in Folly Beach
5.0 out of 5 average rating, 25 reviewsLuxury 6BR Tropical Oasis, Pool, Steps to Beach
Villa in Kiawah Island
5.0 out of 5 average rating, 26 reviewsOcean Front! Beach is steps away. Clean and Crisp!
Villa in Seabrook Island
Seaside Therapy - An iTrip Vacations Home
Villa in Kiawah Island
5.0 out of 5 average rating, 16 reviewsOceanfront Windswept Villa
Villa in Sullivan's Island
4.59 out of 5 average rating, 22 reviewsHaven by AvantStay | Luxury Beachfront Retreat
Villa in Kiawah Island
5.0 out of 5 average rating, 19 reviewsLuxury Penthouse 2 BR 3 Bath Villa with Ocean View
Villa in Isle of Palms
5.0 out of 5 average rating, 4 reviewsOceanfront Villa in Wild Dunes! Community Pool!
Villa in Kiawah Island
4.94 out of 5 average rating, 52 reviewsOpen floor plan 2 Bedroom Turtle Cove Villa
Villa rentals with a pool
Villa in Edisto Island
4.95 out of 5 average rating, 22 reviewsWaves of Change
Villa in Isle of Palms
4.77 out of 5 average rating, 47 reviewsUpdated 2BR | Balcony | Pool | Dock
Villa in Isle of Palms
4.78 out of 5 average rating, 27 reviewsBeachfront IOP Villa with Outdoor Pool. Remodeled!
Villa in Folly Beach
4.68 out of 5 average rating, 38 reviews3BR 1st-Floor | Deck | Pool | Washer/Dryer
Villa in Seabrook Island
5.0 out of 5 average rating, 5 reviewsStunning Water Views Renovated Modern Oasis
Villa in Seabrook Island
4.96 out of 5 average rating, 24 reviewsUpscale, Private,Breathtaking Views
Villa in Johns Island
4.73 out of 5 average rating, 26 reviewsDog friendly villa on 8th hole of golf course
Villa in Johns Island
Tranquil 1BR in High Hammock Villas
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- Rentals with pools James Island
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- Family travel hub Tips and inspiration
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- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes