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Vacation rentals in Los Santos Province

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Top-rated vacation rentals in Los Santos Province

Guests agree: these stays are highly rated for location, cleanliness, and more.

Superhost
Home in Pedasí
Ocean View From The Jungle!
Welcome! 20% off for March Madness!! This home has been recently updated & returned to its original glory. There are 4 well appointed bedrooms, each has its own private bathroom. All bed linens are 100% egyptian cotton. The kitchen is very well stocked and you can be sure that you will be able to cook amazing meals for the whole family. Enjoy your meals outside, overlooking the pool and the jungle or inside... as there are 2 dining areas . The pool is nothing short of spectacular!
Jul 16 – 23
$283 per night
5.0 out of 5 average rating, 3 reviews
Guest favorite
Home in Pedasí
3 min to Pedasi, 5 min to the Beach, Private Pool!
Your family will be close to everything when you stay at this centrally-located place. Outfitted with room to sleep 6 and a fenced yard for your dog, Casa Catch and Relax has it all! Look us up online, Casa Catch and Relax You'll Love - Beach access a short drive or walk away (3 min drive, 10 min walk) - Central to town and local restaurants - Private, fenced outdoor space with pool - Cool days and nights with A/C in every room - Fully equipped kitchen and tons of sleeping space - Wifi
May 5 – 12
$119 per night
4.93 out of 5 average rating, 102 reviews
Guest favorite
Guesthouse in La Enea
Villa de Los Abuelos in Guararé
Get out of the capital city and come and enjoy Panamanian folklore in a rustic yet cozy space with an autochthonous experience. Lounge in the pool or lounge in a hammock, breathe fresh air, close to the ocean, surrounded by wide, natural gardens for a good walk. Close to the Port of Guararé where you will enjoy the best seafood and drinks or enjoy the heart of the best folklore event highlighting the traditions and the best Panamanian polleras.
May 2 – 9
$77 per night
4.95 out of 5 average rating, 40 reviews

Popular amenities for Los Santos Province vacation rentals

Other great vacation rentals in Los Santos Province

Guest favorite
Tiny home in Playa Los Destiladeros
Casita Brisa del Mar
May 8 – 15
$84 per night
4.85 out of 5 average rating, 33 reviews
Guest favorite
Home in Playa Venao
Casa Samambaia - sea view tropical paradise w pool
Aug 8 – 15
$286 per night
5.0 out of 5 average rating, 11 reviews
Guest favorite
Guesthouse in Pedasi
Casa de la Amor Casita
Aug 16 – 23
$110 per night
4.93 out of 5 average rating, 14 reviews
Guest favorite
Guesthouse in Pedasi
A Remote Paradise in nature - Ocean View
Sep 22 – 29
$122 per night
5.0 out of 5 average rating, 19 reviews
Guest favorite
Vacation home in Playa Los Destiladeros
Curcu House: magical beach house & tropical forest
Jun 21 – 28
$137 per night
4.95 out of 5 average rating, 19 reviews
Guest favorite
Villa in Playa Venao
Villa Verde - Luxury&Cozy Villa 1BR #26 BlueVenao
Feb 1 – 8
$196 per night
5.0 out of 5 average rating, 18 reviews
Superhost
Home in Cambutal
Casa Concha and Luna Negra
Nov 2 – 9
$155 per night
5.0 out of 5 average rating, 4 reviews
Superhost
Home in Pedasi
Arrue Coastal Escape
Jun 13 – 20
$225 per night
5.0 out of 5 average rating, 4 reviews
Guest favorite
Villa in PA
Playa Venao, Blue Venao Beach Resort Villa 30
Mar 25 – Apr 1
$399 per night
5.0 out of 5 average rating, 26 reviews
Guest favorite
Vacation home in Las Escobas del Venado
3 BR Family Surf Villa - Benow in Playa Venao
Jan 13 – 20
$320 per night
4.8 out of 5 average rating, 49 reviews
Guest favorite
Villa in Cañas
Residence Denter Tumas
Apr 20 – 27
$500 per night
5.0 out of 5 average rating, 15 reviews
Superhost
Villa in Las Escobas del Venado
Breathtaking Ocean Villa. Casa de Vida
Jul 21 – 28
$520 per night
4.95 out of 5 average rating, 20 reviews

Destinations to explore