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Family-friendly vacation rentals in Mesa de Otay

Find and book unique family-friendly homes on Airbnb

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Popular amenities for Mesa de Otay family-friendly rentals

Family-friendly home rentals with a hot tub

Family- and pet-friendly home rentals

Family-friendly home rentals with a pool

Guest favorite

Home in Las Gaviotas, Mexico

4.98 out of 5 average rating, 243 reviews

Modern Casita with Whitewater Views - Las Gaviotas

Jan 21 – 28

$162 per night
Guest favorite

Guesthouse in San Diego, California

4.94 out of 5 average rating, 333 reviews

The BEST NEST Clean, peaceful, private, affordable

Oct 16 – 23

$96 per night
Guest favorite

Villa in La Mesa, California

4.88 out of 5 average rating, 227 reviews

Summer Sale! Villa w/ Pool, Waterslide & Hot Tub

Aug 21 – 28

$899 per night
Guest favorite

Condo in San Diego, California

4.96 out of 5 average rating, 141 reviews

Beautifully remodeled 10th floor oceanfront condo

Nov 24 – Dec 1

$375 per night
Guest favorite

Yurt in El Cajon, California

4.98 out of 5 average rating, 303 reviews

Glamping @ Eden East

Sep 19 – 26

$103 per night
Guest favorite

Home in San Diego, California

4.94 out of 5 average rating, 203 reviews

Boutique home with view, heated pool, spa + cabana

Nov 18 – 25

$489 per night
Guest favorite

Condo in Rosarito, Mexico

4.9 out of 5 average rating, 101 reviews

OCEANA PAPAS AND BEER 2 FLOOR VIP PENTHOUSE

Oct 30 – Nov 6

$360 per night
Guest favorite

Home in Rosarito, Mexico

4.92 out of 5 average rating, 143 reviews

Fabulous Oceanfront Estate, Sleeps 24 Pool Jacuzzi

Feb 8 – 15

$984 per night

Destinations to explore