Guesthouse vacation rentals in Charleston

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Top-rated guesthouse rentals in Charleston

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Guest favorite
Guesthouse in Charleston
Charleston's Coolest Neighborhood
You can't beat the location! You'll be 5-10 minutes from downtown Charleston, but with free off-street parking, AND you can walk to dozens of bars, restaurants, coffee shops, etc. Avondale is Central to all parts of Charleston, and its a cinch to drive to everywhere from here. This studio apartment is private, modern, and newly renovated. You'll have a kitchenette, grill, outdoor seating, and access to beach equipment. Also only a 5 minute walk to the West Ashley Greenway for biking/jogging!
Jun 29 – Jul 6
$138 per night
4.93 out of 5 average rating, 697 reviews
Guest favorite
Guesthouse in Summerville
★Delightful guest house near historic plantations★
Nestled in the Historic Plantation District between Summerville & Charleston, our timberframe "bunkhouse" offers privacy, comfort & convenience. This 850+ sq ft retreat includes full kitchen & bath, 2 dbl beds, twin bed & plenty of living space. There's a private entrance, so come & go as you please (we're right next door if you need us). We're minutes from Middleton Place, Drayton Hall & Magnolia Gardens, an easy drive to downtown Charleston, historic Summerville, beaches & golf courses.
Feb 3 – 10
$147 per night
4.98 out of 5 average rating, 627 reviews
Guest favorite
Guesthouse in Charleston
Riverland Terrace Guesthouse
Private and quiet guest suite perfect for nature lovers. Our guest house is tucked up against a small marshy area in our backyard on James Island. Located about 5 minutes to downtown Charleston, 5 minutes to John's Island and 15 minutes to Folly Beach. Five minute walk to the Pour House and all terrace area restaurants and the terrace theater. We are a very laid back couple looking for laid back guests who need a quiet and peaceful place to use as their base while exploring Charleston.
May 20 – 27
$100 per night
4.91 out of 5 average rating, 166 reviews

Popular amenities for Charleston guesthouse rentals

Family-friendly guest house rentals

Guest favorite
Guesthouse in North Charleston
Cozy Park Circle, Charleston Guest House
Dec 27 – Jan 3
$79 per night
4.93 out of 5 average rating, 337 reviews
Guest favorite
Guesthouse in Charleston
Spacious Daniel Island Apartment
Sep 23 – 30
$134 per night
4.99 out of 5 average rating, 259 reviews
Guest favorite
Guesthouse in Mount Pleasant
Bungalow Under The Oaks
Jul 2 – 9
$135 per night
4.98 out of 5 average rating, 209 reviews
Guest favorite
Guesthouse in Ridgeville
Pond House Bungalow at Natural Gathering Grounds
Sep 8 – 15
$58 per night
4.82 out of 5 average rating, 206 reviews
Guest favorite
Guesthouse in North Charleston
The Park Circle Clerestory Studio Guest House
May 14 – 21
$146 per night
5.0 out of 5 average rating, 102 reviews
Guest favorite
Guesthouse in Johns Island
Private waterfront apt in the oaks
Aug 12 – 19
$174 per night
4.98 out of 5 average rating, 231 reviews
Guest favorite
Guesthouse in Charleston
The White House of Avondale
Aug 17 – 24
$145 per night
4.95 out of 5 average rating, 317 reviews
Guest favorite
Guesthouse in Summerville
Nina's Cottage -Historic Downtown Summerville
Mar 17 – 24
$120 per night
4.94 out of 5 average rating, 205 reviews
Superhost
Guesthouse in North Charleston
Park Circle Bungalow Loft
Jul 27 – Aug 3
$163 per night
4.86 out of 5 average rating, 434 reviews
Guest favorite
Guesthouse in Charleston
Cozy Island Cottage
Jan 20 – 27
$179 per night
4.93 out of 5 average rating, 312 reviews
Guest favorite
Guesthouse in Charleston
Island Oasis—Near Downtown
May 3 – 10
$186 per night
4.91 out of 5 average rating, 635 reviews
Guest favorite
Guesthouse in Mount Pleasant
Green Garden Studio @greengardenstudio2017
Jul 4 – 11
$154 per night
4.95 out of 5 average rating, 213 reviews

Guest house rentals with a patio

Guest favorite
Guesthouse in Charleston
Studio Apartment Minutes to Downtown Charleston
Dec 12 – 19
$142 per night
4.97 out of 5 average rating, 115 reviews
Guest favorite
Guesthouse in Charleston
Quaint Cottage Studio in Ashley Forest (Avondale)
Jul 10 – 17
$122 per night
4.93 out of 5 average rating, 156 reviews
Guest favorite
Guesthouse in Charleston
Private Backyard With Fire Pit, 15 Min to Downtown
Sep 1 – 8
$300 per night
4.98 out of 5 average rating, 110 reviews
Guest favorite
Guesthouse in Hanahan
The Violet Villa w/ no cleaning fee
Jun 9 – 16
$116 per night
4.98 out of 5 average rating, 60 reviews
Guest favorite
Guesthouse in Goose Creek
The Blue Secret
Apr 8 – 15
$91 per night
5.0 out of 5 average rating, 41 reviews
Guest favorite
Guesthouse in Charleston
BoHo styled casita in adorable neighborhood...
Jun 15 – 22
$157 per night
4.95 out of 5 average rating, 81 reviews
Guest favorite
Guesthouse in Charleston
Spacious 1 bedroom cottage in Avondale
Dec 22 – 29
$130 per night
4.94 out of 5 average rating, 67 reviews
Guest favorite
Guesthouse in Charleston
1/1 sleeps 3 ADU Modern+Amazing!
Apr 30 – May 7
$133 per night
5.0 out of 5 average rating, 14 reviews
Guest favorite
Guesthouse in Charleston
The James: “Tiny” Home b/w Downtown & Folly
Jan 31 – Feb 7
$309 per night
4.98 out of 5 average rating, 51 reviews
Guest favorite
Guesthouse in Johns Island
Driftwood Cottage
Oct 21 – 28
$165 per night
5.0 out of 5 average rating, 36 reviews
Superhost
Guesthouse in Johns Island
Cozy Cottage! 5 mins from Kiawah!
Jul 20 – 27
$170 per night
4.9 out of 5 average rating, 87 reviews
Guest favorite
Guesthouse in Mount Pleasant
Coastal Charm: Village Hideaway
Oct 8 – 15
$268 per night
5.0 out of 5 average rating, 17 reviews

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in Charleston
Cute, Cozy, Charleston Cottage
Jul 29 – Aug 5
$132 per night
4.9 out of 5 average rating, 533 reviews
Guest favorite
Guesthouse in Mount Pleasant
The Boathouse
May 18 – 25
$141 per night
4.93 out of 5 average rating, 362 reviews
Guest favorite
Guesthouse in Mount Pleasant
Old Mt. Pleasant/Shem Creek close to Sullivans/DT
Oct 18 – 25
$176 per night
4.98 out of 5 average rating, 420 reviews
Guest favorite
Guesthouse in Charleston
James Island "La Casita" Nestled btw Beach & City
Jun 15 – 22
$175 per night
5.0 out of 5 average rating, 209 reviews
Guest favorite
Guesthouse in Charleston
Large Guesthouse with Private Dock & Marsh Views
Jul 5 – 12
$263 per night
4.98 out of 5 average rating, 132 reviews
Guest favorite
Guesthouse in Mount Pleasant
Upscale Couple's Escape | Beach & Downtown CHS
Apr 30 – May 7
$242 per night
4.99 out of 5 average rating, 238 reviews
Guest favorite
Guesthouse in Mount Pleasant
Beach, downtown, Alhambra Hall weddings so close!
Jul 28 – Aug 4
$167 per night
4.98 out of 5 average rating, 106 reviews
Guest favorite
Guesthouse in Charleston
Detached Guest Suite
Jan 3 – 10
$116 per night
4.98 out of 5 average rating, 243 reviews
Guest favorite
Guesthouse in Mount Pleasant
Cozy Apartment in Mount Pleasant
Aug 26 – Sep 2
$133 per night
4.97 out of 5 average rating, 216 reviews
Guest favorite
Guesthouse in Charleston
Redesigned suite! 12min to city, pet-friendly
Aug 10 – 17
$148 per night
4.98 out of 5 average rating, 191 reviews
Guest favorite
Guesthouse in Summerville
Tiny Oak Cottage in Historic Downtown Summerville
Sep 29 – Oct 6
$87 per night
4.97 out of 5 average rating, 207 reviews
Guest favorite
Guesthouse in Mount Pleasant
#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Apr 14 – 19
$191 per night
4.98 out of 5 average rating, 252 reviews

Quick stats about guesthouse rentals in Charleston

Total rentals

220 properties

Rentals with dedicated workspaces

90 properties have a dedicated workspace

Rentals with a pool

10 properties have a pool

Pet-friendly rentals

40 properties allow pets

Family-friendly rentals

40 properties are a good fit for families

Total number of reviews

23K reviews

Destinations to explore