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Guesthouse vacation rentals in South Carolina

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Top-rated guesthouse rentals in South Carolina

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Guest favorite
Guesthouse in Bluffton
Bluffton's Tropical Carriage House Getaway
Embrace the inviting atmosphere of this detached garage apartment. The guesthouse features an open-concept living/kitchen/sleeping area, a tropical design, a private entry, a luxury king mattress and blackout window treatments. Spacious carriage house apartment with king size Stearns&Foster mattress. This space offers a living area with sofa, chair, table with barstools and tv with Netflix as well as other apps that you access. *We do not have cable or local channels. The kitchenette has lots of utensils, plates, glasses, toaster, coffee pot, plug-in induction burner with pots and pans, and a panini press. There is also a ceiling fan for temperature control, or if you are like us and want to sleep with the fan on. In addition there is walk-in closet with hangers and luggage rack for you to hang your clothes and keep your luggage. Fresh towels and toiletries are available for your stay. Other amenities include a hair dryer, curling iron, iron and ironing board, beach towels and beach blanket. You have access to the carriage house apartment and all of its amenities. You are welcome to use our backyard as well, and our wonderful bed swing (thanks to Joey's craftmanship) that's on our front porch. We're also willing to run a load of laundry for you if the need should arise. Brittani works from home, so she will normally be able to assist you if you should need anything. We are both available by our cell phone. We are relatively new to the Bluffton/Hilton Head area, but would love to share our finds with you. This southern style hood offers ample sidewalks, ponds for fishing, a playground, and a park. Quaint Old Town Bluffton is a 3 minute drive or 20 minute walk to a number of shops and restaurants. Unfortunately public transportation is not readily available, so if you are not wishing to use your car then you can easily walk to a good bit of amenities or call for an Uber. Our puppy son, Gunner, is a lovable Labradoodle. He is very friendly and will most likely be barking at the door of our home when you arrive, but we promise it's all for show! You might encounter him in the backyard during your visit :)
Apr 23 – 30
$85 per night
Guest favorite
Guesthouse in Abbeville
Quiet, Romantic Loft in the Woods
Come relax for a getaway in our elegant guest loft! Located near the end of a quiet road with lots of wide open fields and beautiful tree lines! Our loft features a cute kitchenette, plenty of closet space, TV(YoutubeTV & Roku), an extremely comfortable bed! The loft is kept very clean and neat and will be stocked with all the essentials. Access to a beautiful 33' above ground pool! We are conveniently located about 5 miles from downtown Abbeville, and only a 10 minute drive to Erskine/Due West!
May 31 – Jun 7
$57 per night
Guest favorite
Guesthouse in Beaufort
Sunset River House
Our quaint little River House rests on the beautifully natural marsh grass banks of the Whale Branch River in a quiet rural neighborhood. It is located only 9 miles from Historic Downtown Beaufort and 15 miles from Parris Island Marine Corps Recruit Depot. Hunting Island State Park's sandy beaches, nature tails, and lighthouse tours are a scenic 40 minute drive away. You can swim, fish, kayak or go boating right from the dock in our own back yard. When you arrive; you won't want to leave!
Sep 29 – Oct 6
$88 per night

Popular amenities for South Carolina guesthouse rentals

Family-friendly guest house rentals

Guest favorite
Guesthouse in Greenville
Historic 19th Century Cabin/Guest House
Nov 2 – 9
$78 per night
Guest favorite
Guesthouse in Ridgeville
Pond House Bungalow at Natural Gathering Grounds
Aug 1 – 8
$63 per night
Guest favorite
Guesthouse in Salem
Mountain Edge Loft
Nov 27 – Dec 4
$68 per night
Guest favorite
Guesthouse in Charleston
Mother in Law in James Island Riverland Terrace
Nov 16 – 23
$95 per night
Guest favorite
Guesthouse in Townville
Lisa’s Lodge
Apr 9 – 16
$80 per night
Guest favorite
Guesthouse in Summerville
★Delightful guest house near historic plantations★
Oct 22 – 29
$145 per night
Guest favorite
Guesthouse in West Columbia
Carriage House: Studio Bed & Bath - Pool & Hot Tub
Jun 2 – 9
$87 per night
Guest favorite
Guesthouse in Charleston
Spacious Daniel Island Apartment
Nov 24 – Dec 1
$122 per night
Guest favorite
Guesthouse in Greer
Executive Suite on a farm @GSP Airport
May 20 – 27
$78 per night
Guest favorite
Guesthouse in Camden
Red Roof Loft @ FireFly Farm
Jul 31 – Aug 7
$79 per night
Guest favorite
Guesthouse in Mount Pleasant
Bungalow Under The Oaks
Aug 10 – 17
$136 per night
Guest favorite
Guesthouse in Charleston
Charleston's Coolest Neighborhood
Aug 10 – 17
$138 per night

Guest house rentals with a patio

Guest favorite
Guesthouse in Fort Mill
Carriage House Suite on Lake Wylie
Jul 3 – 10
$132 per night
Guest favorite
Guesthouse in Charleston
Quaint Cottage Studio in Ashley Forest (Avondale)
Jan 8 – 15
$116 per night
Guest favorite
Guesthouse in Charleston
Private Backyard With Fire Pit, 15 Min to Downtown
Dec 18 – 25
$144 per night
Guest favorite
Guesthouse in Charleston
Studio Apartment Minutes to Downtown Charleston
Aug 8 – 15
$168 per night
Guest favorite
Guesthouse in Columbia
Renovated One Bedroom Guest House by UofSC
May 18 – 25
$63 per night
Guest favorite
Guesthouse in North Charleston
The Park Circle Clerestory Studio Guest House
Apr 1 – 8
$188 per night
Guest favorite
Guesthouse in Campobello
Bungalow on a 3 acre mini farm
Nov 5 – 12
$72 per night
Guest favorite
Guesthouse in Inman
Foothills Favorite
Aug 9 – 16
$73 per night
Guest favorite
Guesthouse in Abbeville
1-bedroom guesthouse in Abbeville, SC
Jul 18 – 25
$69 per night
Guest favorite
Guesthouse in Spartanburg
The Lodge at Pythian Park
Jul 11 – 18
$76 per night
Guest favorite
Guesthouse in Fountain Inn
The Woodlands - Spacious Apt in Central Location!
Jan 10 – 17
$66 per night
Guest favorite
Guesthouse in North Augusta
Lush Bohemian Poolhouse
Jan 16 – 23
$80 per night

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in Beaufort
Buddy's Cottage near everything in Beaufort, SC
Aug 2 – 9
$110 per night
Guest favorite
Guesthouse in Abbeville
Modern Carriage House
May 4 – 11
$84 per night
Guest favorite
Guesthouse in Florence
Midtown Retreat - Guest House in heart of Florence
Aug 4 – 11
$89 per night
Guest favorite
Guesthouse in Lyman
Blue Heron Hideaway Lakeside Retreat
Aug 9 – 16
$117 per night
Guest favorite
Guesthouse in Mount Pleasant
Guesthouse Convenient to Charleston, Shem Creek, and Beaches
Nov 22 – 29
$144 per night
Guest favorite
Guesthouse in Saint Helena Island
Charming Waterfront Cottage with Beautiful Views.
Aug 14 – 21
$150 per night
Guest favorite
Guesthouse in Lexington
Lake front Lake Murray in the Heart of Lexington
May 17 – 24
$211 per night
Guest favorite
Guesthouse in Charleston
Detached Guest Suite
Dec 31 – Jan 7
$118 per night
Guest favorite
Guesthouse in Camden
Camden Coach House Long term stay southern balance
May 25 – Jun 1
$95 per night
Guest favorite
Guesthouse in Charleston
Large Guesthouse with Private Dock & Marsh Views
May 16 – 23
$263 per night
Guest favorite
Guesthouse in Summerville
Tiny Oak Cottage in Historic Downtown Summerville
Dec 30 – Jan 6
$96 per night
Guest favorite
Guesthouse in Charleston
Cute, Cozy, Charleston Cottage
Jul 30 – Aug 6
$131 per night

Destinations to explore