Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Townville
4.88 out of 5 average rating, 230 reviewsLisa’s Lodge
May 29 – Jun 5
Guesthouse in West Columbia
4.94 out of 5 average rating, 597 reviewsCarriage House: Studio Bed & Bath - Pool & Hot Tub
Jun 30 – Jul 7
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 218 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Sep 22 – 29
Guesthouse in Bluffton
4.98 out of 5 average rating, 354 reviewsHickory Trace Carriage House
Sep 28 – Oct 5
Guesthouse in Beaufort
4.98 out of 5 average rating, 359 reviewsThe Wren Guest House
Mar 13 – 20
Guesthouse in Ridgeville
4.82 out of 5 average rating, 212 reviewsPond House Bungalow at Natural Gathering Grounds
Dec 15 – 22
Guesthouse in Greenville
4.92 out of 5 average rating, 580 reviewsHistoric 19th Century Cabin/Guest House
Jul 11 – 18
Guesthouse in Lexington
4.94 out of 5 average rating, 246 reviewsCome Pause and Relax!
Jun 30 – Jul 7
Guest house rentals with a patio
Guesthouse in Fort Mill
4.95 out of 5 average rating, 130 reviewsCarriage House Suite on Lake Wylie
Sep 3 – 10
Guesthouse in Charleston
4.93 out of 5 average rating, 168 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Jan 21 – 28
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jun 20 – 27
Guesthouse in Johns Island
4.91 out of 5 average rating, 104 reviewsCozy Cottage! 5 mins from Kiawah!
Oct 7 – 14
Guesthouse in Columbia
4.95 out of 5 average rating, 147 reviewsRenovated One Bedroom Guest House by UofSC
Aug 31 – Sep 7
Guesthouse in Charleston
4.98 out of 5 average rating, 120 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Sep 12 – 19
Guesthouse in Charleston
4.97 out of 5 average rating, 125 reviewsStudio Apartment Minutes to Downtown Charleston
Apr 13 – 20
Guesthouse in Spartanburg
5.0 out of 5 average rating, 38 reviewsThe Lodge at Pythian Park
Oct 15 – 22
Guest house rentals with a washer and dryer
Guesthouse in Lyman
4.99 out of 5 average rating, 123 reviewsBlue Heron Hideaway Lakeside Retreat
Aug 12 – 19
Guesthouse in Beaufort
4.98 out of 5 average rating, 196 reviewsBuddy's Cottage near everything in Beaufort, SC
Aug 13 – 20
Guesthouse in Abbeville
4.99 out of 5 average rating, 148 reviewsModern Carriage House
May 8 – 15
Guesthouse in Saint Helena Island
4.99 out of 5 average rating, 187 reviewsCharming Waterfront Cottage with Beautiful Views.
Jul 21 – 28
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 405 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Apr 10 – 17
Guesthouse in Florence
4.92 out of 5 average rating, 124 reviewsMidtown Retreat - Guest House in heart of Florence
Oct 5 – 12
Guesthouse in Summerville
4.97 out of 5 average rating, 215 reviewsTiny Oak Cottage in Historic Downtown Summerville
Dec 22 – 29
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Jan 23 – 30
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