House vacation rentals in Downtown San Diego

Find and book unique houses on Airbnb

Top-rated house rentals in Downtown San Diego

Guests agree: these houses are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Guest favorite

Home in San Diego

4.89 out of 5 average rating, 181 reviews

Snazzy Spot with yard near beaches and downtown

Welcome to this modern get-away that is as bright and cheerful as a sunny day! You'll be sure to be rejuvenated here after your trips to the nearest beach (only a 15 minute drive) and outings on the town (only 10 minutes by car to downtown). This spot includes a private parking spot and a private yard. Yours to enjoy are a very comfortable queen bed, TV in bedroom, Fast WiFi, and a well stocked kitchenette. There are also two canyon hikes within a 2 minute walk with views of downtown for sunset.

Nov 6 – 13

$92 per night

Guest favorite

Home in Downtown San Diego

4.95 out of 5 average rating, 111 reviews

NEW Luxury 3BR HOUSE❤️of DT Walk Petco w/Garage AC

Located in the heart of Downtown San Diego, this unique house has been completely remodeled and re-imagined to make your stay unforgettable. Designed with the eye toward comfort and entertainment. 7 min walk Petco Park/14 min walk to Convention Center/6 min to Zoo/9 min Airport/12 min to SeaWorld/9 min to Coronado *Stunning bathrooms w/ dual showers, tub, smart glass *Full Kitchen, AC Central *SONOS Sound System, 4K TVs every room *Walk to coffee, yoga & gyms, dining, entertainment, shopping!

Oct 4 – 11

$381 per night

Guest favorite

Home in South Park

4.84 out of 5 average rating, 428 reviews

San Diego Private Casita

A stand-alone private casita in the charming, convenient, and unique South Park neighborhood of San Diego. Due to covid, we are taking extra care to disinfect and clean. And for your convenience, extra cleaning supplies and disposable gloves are available for you. The casita is a stand-alone building, with its own entrance, patio, and privacy. Recent reviews mentioned poor water pressure in shower. I am happy to announce that this has been fixed! We welcome people of all backgrounds.

Sep 2 – 9

$86 per night

Guest favorite

Home in San Diego

5.0 out of 5 average rating, 310 reviews

Golden Hill Tree House

The Golden Hill Tree House is an urban oasis hiding in the branches of two mature trees in the heart of San Diego. While you enjoy elevated privacy you can also treat yourself to a soaker tub with double shower heads or settle down in a cozy reading nook to enjoy a good book! You'll also be walking distance to some amazing restaurants and super close to the best of San Diego, including downtown, the beach and the zoo! It's a perfect place to recharge after a long day of business or pleasure!

Apr 16 – 23

$154 per night

Guest favorite

Home in North Park

4.98 out of 5 average rating, 337 reviews

Modern 2BR Spanish Home on Balboa Park, 1M to Zoo

★ Condé Nast rated top in SD ★ Luxury 2BR/1BA home w/ AC ★ Across the street from Balboa Park, concerts & sunsets ★ 4 min to Zoo ★ 15 min to Beach ★ 7 min walk to North Park entertainment corridor - breweries, restaurants, cafes, yoga & shops ★ Family-friendly space, crib ★ Easy free street parking ★ Fully remodeled in 2022, professionally designed ★ Fresh artisan coffee, Nespresso ★ 4K TV, Netflix, HBO ★ We welcome people from all backgrounds ★ Security camera at exterior entry (none inside)

Nov 8 – 15

$280 per night

Guest favorite

Home in City Heights

4.92 out of 5 average rating, 141 reviews

Private Studio

Enjoy a cozy studio all to yourself, just minutes from University Ave, walking distance to shopping and food like Denny's Jamba Juice and Starbucks. Less than 15 min to Gaslamp (Downtownthe San Diego zoo, North Park, the 805, 15, and other great places nearby. This is a unit with a private entrance and black out shades and a gated driveway for security. California King with plush top Serta mattress. check in can be earlier. Please ask PLEASE READ INFO to ensure it's a fit for you.

Sep 17 – 24

$83 per night

Guest favorite

Home in San Diego

4.95 out of 5 average rating, 396 reviews

Admire Harbor Views from the Porch at a City Gem

Unwind in a cozy colorful casita in this light-filled 1920s Spanish bungalow with Mexican accents and a casual feel.Take a walk into Little Italy for dinner. What’s best, is how close you are to so much, all without needing a car. A very small single car garage is provided, think compact car. Street parking is free but challenging at times. The house is located directly below the incoming flight path. You are encouraged to read the reviews regarding this. Ideal for four or less persons.

Oct 16 – 23

$187 per night

Superhost

Home in Downtown San Diego

4.89 out of 5 average rating, 608 reviews

#1 LOCATION - Rare Luxury Home in Downtown

***THE BEST RATED RENTAL IN DOWNTOWN SAN DIEGO*** Location doesn't get better than this! Right in the heart of the lively Little Italy area in downtown San Diego. San Diego's best restaurants and nightlife in your backyard. Just blocks from the waterfront and a short Uber or walk to the Gaslamp, Convention Center & Zoo! All the frills: + Prime location! 98/100 Walker Score rating + Private parking + Private Sundeck & Backyard Stay at this modern luxury home for your next trip!

Jul 20 – 27

$649 per night

Guest favorite

Home in San Diego

4.89 out of 5 average rating, 366 reviews

Ocean Beach Close to all

*We are Covid-19 aware! We have taken extra precautions--sanitizing all surfaces possible, including remote controls, door handles, light switches, etc... after each visit! And we open all the windows to aerate before the next guests! One bedroom granny flat, separate entrance with off street parking for midsize car or smaller. Three blocks to the beach. Located at the edge of downtown OB close to all restaurants and night life. Centrally located to all main San Diego attractions.

Mar 25 – Apr 1

$99 per night

Guest favorite

Home in San Diego

4.98 out of 5 average rating, 274 reviews

Stunning Remodel 4 BR/3 BA Downtown Gaslamp Petco

Book this home for the ultimate downtown San Diego experience. It is spectacular in every way; no detail has been overlooked. There is simply nothing else like it. Torn down to the studs during a $400K remodel taking over 18 months to complete. Designed to be a vacation rental. No detail was overlooked. Read the reviews. It a short walk to Gaslamp Quarter, Convention Center or Petco Park. All Covid cleaning protocols are followed. Legal short-term rental permit STR-00024.

Oct 16 – 23

$667 per night

Superhost

Home in San Diego

4.95 out of 5 average rating, 149 reviews

*Modern Studio Close to Everything*

Beautiful Studio in the heart of Historic Sherman Heights. We are conveniently located on Market Street which is a busy transit corridor leading to downtown San Diego, steps from a bus stop, blocks from the trolley, and easy access to the freeways. The location is 1.3 miles from Convention Center (27-minute walk.) Lots of nearby places to eat and shop for groceries.

Oct 24 – 31

$128 per night

Guest favorite

Home in San Diego

4.96 out of 5 average rating, 142 reviews

Cheerful 2 bedroom house in heart of San Diego

Nestled in the heart of Golden Hill, we are located within a 10 minute drive to Ocean Beach & Coronado and a mere 6 minute drive from the San Diego Zoo, Balboa park and Downtown. With a walkability score of 85, we hope you can enjoy everything San Diego has to offer.

Jan 26 – Feb 2

$210 per night