Guesthouse vacation rentals in San Diego

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 344 reviews

Diamond Villa in the Heart of Pacific Beach

3 blocks to the beach & 2 blocks off main st, newly constructed detached living space w/private entrance & shared yard: spacious 1 bedroom, 1 bath, lg living rm w/an accordion glass door to patio/deck, 2 flat screen TVs w/cable & wifi , leather sofas, gas fireplace, kitchenette, gas grill, propane heater on deck, top level has wet bar, chairs & gas fit pit, bay & ocean peek views from top level, private entrance, outdoor warm shower for after beach rinse, Jacuzzi & wood fire pit in shared yard

Oct 6 – 13

$121 per night

Guest favorite

Guesthouse in San Diego

4.96 out of 5 average rating, 472 reviews

Romantic Private Garden Studio Near Downtown

A magical private garden surrounds a tiny studio (240 sq ft) with kitchenette in historic residential district, 10 blocks to East Village and Petco BallPark, near Gaslamp Quarter, and one mile to Convention Center and downtown. Easy access to freeways, very close to Balboa Park, San Diego Zoo, and Coronado Island. Airport and train station less than 15 min. We offer a safe, sweet, and contemplative getaway near the city, with WiFi but no TV. One pet OK only with prior approval. 420 friendly.

Apr 5 – 12

$115 per night

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 447 reviews

Private Cottage in Walkable North Park w/AC

Welcome to our charming private Airbnb in vibrant North Park! Enjoy the perfect blend of comfort and convenience for your San Diego stay. Walk to restaurants, coffee shops, art galleries, wine bars, breweries, yoga studios & various boutiques. Nature lovers will adore the nearby Balboa Park with its stunning gardens and cultural attractions. Downtown, Gaslamp Quarter, beaches, and the famous San Diego Zoo are easily accessible. Book and create lasting memories in this dynamic neighborhood.

May 25 – Jun 1

$109 per night

Guest favorite

Guesthouse in San Diego

4.93 out of 5 average rating, 356 reviews

Cozy Ocean Beach Casita

This cozy, clean casita is just 4 blocks to the beach, pier, great surfing, restaurants, bars, shopping, and Sunset Cliffs. You’ll love it for its walkability to everything you need. The casita is only 120 square feet, a very small space (small studio with everything in one room including the bathroom), for single occupancy only, but with everything you need to enjoy a San Diego getaway. It is great for solo travelers who want to be near the heart of Ocean Beach, San Diego, California.

Sep 17 – 24

$92 per night

Guest favorite

Guesthouse in Encinitas

4.86 out of 5 average rating, 228 reviews

Sunset/Ocean View Guest House! Minutes to Beach

Sunset/Ocean view guest house (one bedroom with a sofa bed)--386 Sunset Drive, 92024. Quiet residential neighborhood, close to downtown Encinitas, and half a mile from Moonlight Beach. Balcony features a propane barbecue, table, chairs, chaise lounge, and a distant view of the sunset and ocean. Living room/dining/kitchen area includes sofa bed. Living room features a 45" flat screen and DVD player. Bedroom includes a natural gas fireplace, television, and DVD player.

Jan 5 – 12

$126 per night

Guest favorite

Guesthouse in San Diego

4.98 out of 5 average rating, 185 reviews

North Park Garden Retreat Casita

Nestled between the urban neighborhoods of North and South Park, our sanctuary within the heart of the city is surrounded by a secret garden that gives the impression of a tropical oasis. The private casita is tucked in the backyard of the Host’s home and has french doors which open to the lush greenery of the garden. Whether vacationing, traveling for work, or looking for an ideal space for relaxation and renewal, this is the perfect place to enjoy your San Diego stay.

Sep 5 – 12

$95 per night

Superhost

Guesthouse in La Jolla

4.82 out of 5 average rating, 425 reviews

Stunning studio in the heart of La Jolla

The studio has been totally refurnished and includes a King size bed, fridge/freezer, microwave, loveseat and all the amenities for a very enjoyable stay. A beautiful private studio with a spacious patio, ideally located within mins to the cosmopolitan La Jolla Village, restaurants, coffee shops, boutique stores, La Jolla cove, La Jolla Shores beach, Vons grocery store and so much more. The studio is at the rear of the main house which is also rented.

Mar 1 – 8

$114 per night

Guest favorite

Guesthouse in San Diego

4.91 out of 5 average rating, 413 reviews

Mission Hills Charming suite, walkable to all.

Heart of Mission Hills, upscale area, this private guest suite, separate from the house, is perched above the pool (separate building from main house), own entrance; sure to provide privacy. We are minutes from airport, walking distance to coffee & restaurants and central to all of SD. Please note this property is wiped down after each visit with Clorox as well as all linens washed. We also don’t rent back to back giving time for thorough cleaning.

Oct 15 – 22

$88 per night

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 183 reviews

Fresh, hip and cozy private North Park guest house

Enjoy peaceful sunny San Diego days listening to the palm trees sway in this private backyard garden retreat set behind a 1925 California craftsman. The guest house is tucked away in a quiet quintessential Southern California neighborhood while only being a short and easy walk to amazing restaurants, world class breweries and cozy coffee shops. Balboa Park, the San Diego Zoo, beaches and downtown are all a few minutes drive away.

Nov 7 – 14

$111 per night

Guest favorite

Guesthouse in San Diego

4.96 out of 5 average rating, 125 reviews

Brand New Modern North Park View Apartment

This brand new North Park apartment is the perfect place to enjoy San Diego. The home is located on a quiet street in close proximity to Balboa Park, the San Diego Zoo, Downtown, Sea World, Old Town, Coronado Island, Seaport Village, and the airport. It is in walking distance to a number of renown restaurants, coffee shops, and breweries. Beautiful sunset views allow you to relax after a long day of taking in the city.

Nov 6 – 13

$99 per night

Guest favorite

Guesthouse in San Diego

4.97 out of 5 average rating, 189 reviews

California Cottage in North Park

Walking along side the main house into this secluded cottage, you’ll embark on your own vacay just 10 minutes from the airport. This converted separated garage is a home away from home with walking distance to University Ave with Communal Coffee for breakfast, and outdoor dinner dinning at Louisiana Purchase. If the zoo is what you desire, it is not a far walk but a little hike through the canyon is required.

Oct 3 – 10

$96 per night

Guest favorite

Guesthouse in San Diego

4.96 out of 5 average rating, 167 reviews

Chez Christy

Cozy, quiet studio in the heart of Pacific Beach. Quick access to beaches, Pacific Beach Pier, Mission Beach, Mission Bay, shops, bars, and restaurants. Miles of walking and biking paths skirt the water; recreational opportunities abound. Fast & reliable WiFi and proximity to UCSD make this an ideal place for visiting professionals. We offer extended stay discounts as well, automatically applied.

Oct 25 – Nov 1

$134 per night