Mansion vacation rentals in Panama
Find and book unique mansions on Airbnb
Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Home in Playa Bluff
5.0 out of 5 average rating, 15 reviewsJungle House 100m from the beach
Apr 8 – 15
Cottage in Altos del Maria
4.93 out of 5 average rating, 98 reviewsCabin with Spectacular Mountain View
Aug 5 – 12
Condo in Maria Chiquita
5.0 out of 5 average rating, 18 reviewsPlaya Escondida Lux Beachfront Haven:Oceanview Apt
Oct 7 – 14
Villa in Buenaventura, El Chirú
4.85 out of 5 average rating, 40 reviewsLake House | Pool | King Beds | Next to Beach Club
Jul 10 – 17
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Jul 12 – 19
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Apr 16 – 23
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Jun 9 – 16
Villa in Panamá
5.0 out of 5 average rating, 30 reviewsBreathtaking Views Mansion w/King Beds
Oct 17 – 24
Luxury mansion rentals
Home in Panamá
5.0 out of 5 average rating, 6 reviewsUnique 4 room house - direct access to the beach
Feb 17 – 24
Apartment in Maria Chiquita
4.95 out of 5 average rating, 20 reviewsPenthouse in Playa Escondida 4 bedrooms
Dec 12 – 19
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Jul 24 – 31
Villa in Punta Chame
4.93 out of 5 average rating, 14 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Jan 8 – 15
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
May 5 – 12
Villa in Río Hato
4.92 out of 5 average rating, 73 reviews(Panama) Beach house with golf course.
May 4 – 11
Cabin in Panama
4.92 out of 5 average rating, 12 reviewsCasa de Playa Portobelo Caribe
Apr 3 – 10
Home in Coronado
4.7 out of 5 average rating, 20 reviewsCHARMING ALMAR FRONT HOUSE WITH PISCINA-CORONADO
Aug 26 – Sep 2
Pet-friendly mansion rentals
Apartment in San Carlos District
4.99 out of 5 average rating, 79 reviewsAmazing Oceanfront apartment in San Carlos
Nov 20 – 27
Condo in San Carlos District
4.97 out of 5 average rating, 37 reviewsPunta Caelo Beach Front View
Jan 15 – 22
Home in San José
5.0 out of 5 average rating, 17 reviewsαlkeyler| Luxury Mini Resort 12 PERS @Punta Barco
Aug 29 – Sep 5
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Nov 29 – Dec 6
Villa in Costa Esmeralda
5.0 out of 5 average rating, 13 reviewsSpectacular 600-meter oceanfront beach house
Dec 14 – 21
Apartment in El Chirú
4.94 out of 5 average rating, 84 reviewsBuenaventura Golf & Beach Resort Lux Apartment
Oct 25 – Nov 1
Home in Panamá
5.0 out of 5 average rating, 7 reviewsWonderful House with Terrace and Sea View
Nov 19 – 26
Home in Provincia de Panamá Oeste
4.88 out of 5 average rating, 16 reviewsLuxurious beach front home in Veracruz
Oct 18 – 25
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