Guesthouse vacation rentals in Johns Island
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Johns Island
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Johns Island guesthouse rentals
Family-friendly guest house rentals
Guesthouse in North Charleston
4.94 out of 5 average rating, 346 reviewsCozy Park Circle, Charleston Guest House
Aug 30 – Sep 6
Guesthouse in Charleston
4.99 out of 5 average rating, 263 reviewsSpacious Daniel Island Apartment
Feb 17 – 24
Guesthouse in Charleston
4.91 out of 5 average rating, 648 reviewsIsland Oasis—Near Downtown
Oct 21 – 28
Guesthouse in Mount Pleasant
4.95 out of 5 average rating, 220 reviewsGreen Garden Studio @greengardenstudio2017
Oct 23 – 30
Guesthouse in Ridgeville
4.82 out of 5 average rating, 213 reviewsPond House Bungalow at Natural Gathering Grounds
Sep 17 – 24
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Aug 10 – 17
Guesthouse in Charleston
4.93 out of 5 average rating, 317 reviewsCozy Island Cottage
Nov 1 – 8
Guesthouse in Summerville
4.94 out of 5 average rating, 212 reviewsNina's Cottage -Historic Downtown Summerville
Mar 1 – 8
Guest house rentals with a patio
Guesthouse in Charleston
4.98 out of 5 average rating, 123 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Feb 15 – 22
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Apr 22 – 29
Guesthouse in Johns Island
5.0 out of 5 average rating, 53 reviewsDriftwood Cottage
Apr 3 – 10
Guesthouse in Charleston
5.0 out of 5 average rating, 13 reviewsGas Light Carriage House James Island
Aug 13 – 20
Guesthouse in Charleston
5.0 out of 5 average rating, 12 reviewsLowcountry Guesthouse
Jul 15 – 22
Guesthouse in Charleston
5.0 out of 5 average rating, 23 reviews1/1 sleeps 3 ADU Modern+Amazing!
Jul 9 – 16
Guesthouse in Charleston
4.98 out of 5 average rating, 45 reviewsCountry in the City, "The Outback"
Feb 25 – Mar 4
Guesthouse in Charleston
4.94 out of 5 average rating, 90 reviewsBoHo styled casita in adorable neighborhood...
Sep 25 – Oct 2
Guest house rentals with a washer and dryer
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Jan 20 – 27
Guesthouse in Charleston
4.9 out of 5 average rating, 548 reviewsCute, Cozy, Charleston Cottage
Oct 13 – 20
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 436 reviewsOld Mt. Pleasant/Shem Creek close to Sullivans/DT
Nov 2 – 9
Guesthouse in Charleston
5.0 out of 5 average rating, 143 reviewsThe Guesthouse at Old Orchard
Sep 19 – 26
Guesthouse in Charleston
4.99 out of 5 average rating, 206 reviewsRedesigned suite! 12min to city, pet-friendly
Sep 22 – 29
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 248 reviewsUpscale Couple's Escape | Beach & Downtown CHS
Jul 5 – 12
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 258 reviews#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!
Jul 16 – 23
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 252 reviewsShem Creek Bungalow: Coastal Comfort Redefined
Sep 19 – 26
Quick stats about guesthouse rentals in Johns Island
Total rentals
40 properties
Wifi availability
40 properties include access to wifi
Rentals with dedicated workspaces
10 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Total number of reviews
5.7K reviews
Nightly prices starting at
$40 before taxes and fees
Destinations to explore
- Savannah Vacation rentals
- Hilton Head Island Vacation rentals
- Kiawah Island Vacation rentals
- Tybee Island Vacation rentals
- Folly Beach Vacation rentals
- Surfside Beach Vacation rentals
- Mount Pleasant Vacation rentals
- Hilton Head Vacation rentals
- Atlanta Vacation rentals
- Orlando Vacation rentals
- Charleston Vacation rentals
- Myrtle Beach Vacation rentals
- House rentals United States
- Guesthouse rentals United States
- House rentals Myrtle Beach
- House rentals Charleston
- Guesthouse rentals Charleston
- House rentals Savannah
- Guesthouse rentals Savannah
- House rentals South Carolina
- Guesthouse rentals South Carolina
- Rentals with breakfast Johns Island
- Waterfront rentals Johns Island
- Rentals with pools Johns Island
- Rentals with a patio Johns Island
- House rentals Johns Island
- Fitness-friendly rentals Johns Island
- Rentals with beach access Johns Island
- Kid-friendly rentals Johns Island
- Rentals with a washer and dryer Johns Island
- Family-friendly rentals Johns Island
- Apartment rentals Johns Island
- Monthly Rentals Johns Island
- Rentals with a kayak Johns Island
- Private suite rentals Johns Island
- Pet-friendly rentals Johns Island
- Rentals with a fireplace Johns Island
- Rentals with lake access Johns Island
- Rentals with a hot tub Johns Island
- Rentals with outdoor seating Johns Island
- Rentals with a fire pit Johns Island
- Townhouse rentals Johns Island
- House rentals Charleston County
- Guesthouse rentals Charleston County
- Cabins United States
- Treehouses United States
- Glamping United States
- Tiny Houses United States
- Beach Houses United States
- Campers and RVs United States
- Lakehouses United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Family travel hub Tips and inspiration
- Family budget travel Get there for less
- Vacation ideas for any budget Make it special without making it spendy
- Travel Europe on a budget How to take the kids to Europe for less
- Outdoor adventure Explore nature with the family
- Bucket list national parks Must-see parks for family travel
- Kid-friendly state parks Check out these family-friendly hikes