Guesthouse vacation rentals in La Mesa
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Top-rated guesthouse rentals in La Mesa
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa guesthouse rentals
Family-friendly guest house rentals
Guesthouse in La Mesa
4.85 out of 5 average rating, 183 reviews(2) US Entire upstairs Apartment MT HELIX
Guesthouse in San Diego
4.97 out of 5 average rating, 299 reviewsPrivate Guest House with a View
Guesthouse in Talmadge
4.99 out of 5 average rating, 368 reviews*Private Canyon Retreat: Your Own Guesthouse*
Guesthouse in La Mesa
4.86 out of 5 average rating, 139 reviewsCozy Cottage
Guesthouse in Kensington
4.97 out of 5 average rating, 515 reviewsCentral & Serene Secret Garden Guesthouse
Guesthouse in Kensington
4.96 out of 5 average rating, 257 reviewsYour Kensington Bungalow
Guesthouse in Allied Gardens
4.94 out of 5 average rating, 337 reviewsThe BEST NEST Clean, peaceful, private, affordable
Guesthouse in City Heights
4.92 out of 5 average rating, 246 reviewsNorth Park Garden Studio
Guest house rentals with a patio
Guesthouse in La Mesa
4.84 out of 5 average rating, 127 reviewsPrivate Studio with Panoramic View
Guesthouse in La Mesa
4.96 out of 5 average rating, 121 reviewsSan Diego Newly Built Private Guesthouse (Sleep 5)
Guesthouse in Adams North
4.98 out of 5 average rating, 109 reviewsStunning Patio! King Bed, Walkable, Games, Parking
Guesthouse in Lakeside
4.94 out of 5 average rating, 107 reviewsSky Mesa-Adorable Cottage on the Hill
Guesthouse in San Diego
4.85 out of 5 average rating, 128 reviewsPrivate, beautiful 1-bedroom 2 story guest house
Guesthouse in Spring Valley
4.97 out of 5 average rating, 119 reviewsLoft Cabin-Night Cinema+Hot Soaking Tub+Views!
Guesthouse in San Diego
4.93 out of 5 average rating, 128 reviewsModern Guest House with pool, steps to SDSU
Guesthouse in Chula Vista
4.98 out of 5 average rating, 98 reviewsNew! Beautiful Private Casita- King Bed & Office
Guest house rentals with a washer and dryer
Guesthouse in El Cajon
4.96 out of 5 average rating, 136 reviewsMt Helix Studio Loft with Mountain Views
Guesthouse in Talmadge
4.96 out of 5 average rating, 115 reviewsRelax in a Centrally Located, Modern Guest House
Guesthouse in El Cajon
4.99 out of 5 average rating, 157 reviewsModern mountain guest house. Incredible views
Guesthouse in Normal Heights
4.95 out of 5 average rating, 123 reviews1BR Casita in the Heart of Kensington!
Guesthouse in Golden Hill
4.95 out of 5 average rating, 301 reviews*BEAUTIFUL* Sunny Home in Golden Hill
Guesthouse in Mira Mesa
4.95 out of 5 average rating, 117 reviewsAdorable studio/private entrance/reserved parking
Guesthouse in North Park
4.99 out of 5 average rating, 135 reviewsCarrie’s North Park Casita, in Heart of San Diego
Guesthouse in Talmadge
4.83 out of 5 average rating, 215 reviewsCozy Cottage
Quick stats about guesthouse rentals in La Mesa
Total rentals
60 properties
Wifi availability
60 properties include access to wifi
Rentals with dedicated workspaces
30 properties have a dedicated workspace
Pet-friendly rentals
10 properties allow pets
Total number of reviews
3.9K reviews
Nightly prices starting at
$50 before taxes and fees
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