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Lake house vacation rentals in South Carolina

Find and book unique lake houses on Airbnb

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Top-rated lake house rentals in South Carolina

Guests agree: these lake houses are highly rated for location, cleanliness, and more.

Guest favorite
Home in Inman
LakingitEz..3BR/2BA amazing sunsets & hot tub
LAKEFRONT, awesome sunsets, amazing neighborhood with loads of charm! 3BR/2BA house on secluded acre plus wooded lot. Relax on large screened in porch with amazing lake views or in the hot tub built in deck. 2 bedrooms on main (king & queen) with hall bath & laundry. The upper loft bedroom has 2 full beds & bathroom overlooking the lake. Pet friendly w/fee fenced in backyard with doggie ramp! Awesome location just minutes to both I-26 and I-85. Easy access to Spartanburg, Greenville, & Greer!
$229 per night
Guest favorite
Home in Westminster
Waterfall Views, Lake Hartwell, Highland Architect
Come and enjoy nature with 100+ acres to roam. Paths for long walks. Architect James Fox designed this cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.
$424 per night
Guest favorite
Home in Easley
“Lake House Paradise” Waterfront Oasis
“Lake Paradise” is exquisitely furnished with 2 bedrooms and 1 and a half baths. Your Master Suite has its own screened in porch with private lake access. Wake up from your master suite to views from your bed of the water. Your en suite Master Bathroom has a large luxury marble shower. You will spend many hours of relaxation and peace in the most desirable location in the southeast. Visit Greenville SC's downtown just 15 minutes away. Clemson football Stadium is 20 miles away.
$131 per night

Popular amenities for South Carolina lake house rentals

Waterfront lakehouse rentals

Guest favorite
Home in Chappells
Greenwood Lake Front, FirePit, Outside Kitch, Dock
$115 per night
Guest favorite
Home in Santee
Santee lakefront home, big water right off I-95
$529 per night
Guest favorite
Home in Waterloo
Best Lake Front w Floating Dock/Firepit-Sleeps 10
$167 per night
Guest favorite
Home in Anderson
Broadway Lake Retreat in Anderson, SC
$147 per night
Guest favorite
Home in Summerton
Cozy Lake Living
$115 per night
Guest favorite
Home in Inman
Beautiful Lakefront Home on Over an Acre
$100 per night
Guest favorite
Home in Lexington
Lakefront home on Lake Murray with private dock
$443 per night
Guest favorite
Home in Iva
LakeFront W/ Dock & Kayaks! 2 Bed/2 Bath
$134 per night
Guest favorite
Home in Inman
Maggie's Lake House
$276 per night
Superhost
Home in Hilton Head Island
FREE Heated Pool, Walk to Beach, Elevator, Theater
$181 per night
Guest favorite
Home in Hardeeville
Swim, fish, kayak near Savannah and HHI
$190 per night
Guest favorite
Home in Lexington
Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.
$225 per night

Pet-friendly lake house rentals

Guest favorite
Home in North Charleston
Hot Tub Haven: 7 Beds Endless Summer
$223 per night
Guest favorite
Home in Aiken
Beside Still Waters Country Cottage
$145 per night
Guest favorite
Home in Bluffton
Old Town Bluffton Cottage - Includes Golf Cart!
$324 per night
Guest favorite
Home in Anderson
Lake Living with Amazing Views of Lake Hartwell
$169 per night
Guest favorite
Home in Greenville
Park Cottage at State Park -15min Dwtn GVL, Furman
$149 per night
Guest favorite
Home in Modoc
Ivy’s Escape (water front) at Lake Thurmond
$325 per night
Guest favorite
Home in Iva
Moonshine Bay
$150 per night
Guest favorite
Home in Easley
Large lake house - 15 min to Downtown Greenville
$421 per night
Guest favorite
Home in Myrtle Beach
*Clean *fenced yard * Grill * Affordable
$129 per night
Guest favorite
Home in Anderson
Lake Escape
$115 per night
Guest favorite
Home in Anderson
Lake House, close to Clemson Kayaks & Paddleboards
$205 per night
Superhost
Home in Cross Hill
Book now for an amazing vacay
$185 per night

Private lake house rentals

Guest favorite
Home in Gilbert
10 Mile View on Lake Murray w/ Dock and Ramp
$219 per night
Guest favorite
Home in Summerton
Ultimate Lake Marion Dream Home W/Pool & Swim Spa
$399 per night
Guest favorite
Home in Anderson
Lakefront dock *Hot tub* Anderson Clemson King bed
$156 per night
Guest favorite
Home in Gilbert
Ultra Modern Lake Murray Villa | Magnificent Views
$130 per night
Guest favorite
Home in Chapin
5-Star Waterfront on Lake Murray | Fire Pit
$220 per night
Guest favorite
Home in Waterloo
Lakefront Home with Hot Tub! Kayaks,SUP's,Fireplace! King beds, PingPong, CornHole!
$175 per night
Guest favorite
Home in Fair Play
Waterfall Cove - East
$139 per night
Guest favorite
Home in Charleston
Waterfront Home Near Downtown!
$105 per night
Guest favorite
Home in Camden
Best Wateree Sunsets, many amenities w/ king bed!
$171 per night
Guest favorite
Home in Inman
Casa del Lago...Come Relax...You are on Lake Time!
$225 per night
Guest favorite
Home in Manning
Jewel on the Lake
$178 per night
Guest favorite
Home in Easley
Luxurious 3BR on Lake Saluda w/ Kayaks, Fire Pit
$149 per night

Destinations to explore