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Hotel vacation rentals in South Carolina

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Top-rated hotel rentals in South Carolina

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

Guest favorite
Resort in Myrtle Beach
1st Floor/King Bed & Starbucks Grand Cayman Resort
STARBUCKS ON SITE!!😎 There's no waiting for elevators😎 with a Ground floor unit located @ Grand Cayman Oceanfront Resort & beautifully decorated sleeps 4 with a comfy 🫅king bed and 👸queen sofa sleeper, a south side ocean view and an efficiency kitchen. It is a spacious studio condo. Indoor parking😎 just steps from the room. The resort has a 4 story waterslide, lazy river, hot tubs, pools, tiki bar.😎 The famous River City Bar & Grill next to the resort voted best hamburgers on the beach!
Oct 17 – 24
$94 per night
Guest favorite
Resort in Myrtle Beach
Ocean View, Private Balcony, Renovated Suite
Ocean front, one bedroom suite within the Carolina Winds Resort. Enjoy a beautiful ocean view from your private balcony. Guests will have access to 2 pools (one indoor), 3 hot-tubs, a lazy river and a kiddie-pool. The resort offers direct beach access, seasonal on-site bar/restaurant & Snack Shack. The property is smoke-free, with coin operated laundry & free parking. This newly renovated unit is equipped with a full kitchen, Queen Beds, a Murphy Bed, 2 Smart TVs, a full bath, and free WiFi.
Nov 3 – 10
$69 per night
Guest favorite
Nature lodge in Charleston
The Garden Folly Guest House
Our architect said, “this is NOT a garage, it’s a Garden Folly!” Our Guest House has a bird’s eye view of the rose covered pecan tree and a vista of the marsh and the Wappoo Creek. When we rebuilt our 1930's garage we saved all the beaded siding and pine floor. My husband enjoyed incorporating many design elements and creative ideas. It was quickly becoming the Taj Garage. We decided it was just the kind of property we enjoy when we travel, so, Voila! we decided to share it with you!
Nov 9 – 16
$175 per night

Popular amenities for South Carolina hotel rentals

Family-friendly hotel rentals

Resort in Hilton Head Island
Oceanfront, Brand new Luxury Suite!!
Apr 6 – 13
$279 per night
Hotel room in Myrtle Beach
Wyndham Seawatch Plantation * 2BR
Apr 4 – 11
$529 per night
Resort in Myrtle Beach
2 Bdrm - South Beach Resort - Myrtle Beach, SC
Apr 23 – 28
$225 per night
Resort in Myrtle Beach
Myrtle Beach, Ocean Front Apt, July 7- July 14
Jan 6 – 13
$170 per night
Superhost
Resort in Myrtle Beach
1 bdrm condo, South Beach Resort, Beach Access
Nov 10 – 17
$325 per night
Guest favorite
Hotel room in Clemson
Two private rooms with bathroom
Apr 12 – 19
$295 per night
Superhost
Resort in Myrtle Beach
Carolina Grande - 1 Bedroom
$118 per night
Hostel in Charleston
The Goldman Room @ The Annex
Nov 12 – 19
$78 per night
Hotel in Charleston
Charming Historic Inn*
Jul 28 – Aug 4
$199 per night
Resort in Myrtle Beach
Oceanfront 2 Bedroom-Sandy Beach 1612 - Sleeps 8!
Dec 29 – Jan 5
$196 per night
Hotel in Myrtle Beach
Serendipity King Room w/ Kitchen
Jun 22 – 29
$131 per night
Hotel in North Charleston
Apartment Style Living
Jul 27 – Aug 3
$65 per night

Hotel rentals with a pool

Superhost
Resort in Myrtle Beach
Endless summer vibes Oceanview resort lazy river
Aug 15 – 22
$157 per night
Guest favorite
Boutique hotel in Murrells Inlet
The Inlet Cottage Guests Suite
Jan 21 – 28
$62 per night
Guest favorite
Resort in Myrtle Beach
Full condo with a million dollar view of the ocean
Oct 13 – 20
$66 per night
Superhost
Hotel in Myrtle Beach
Ocean View Suite w. Rooftop Pool
Jan 1 – 8
$97 per night
Guest favorite
Resort in Myrtle Beach
Beautiful Ocean front Unit.
Aug 28 – Sep 4
$131 per night
Guest favorite
Resort in Myrtle Beach
Ocean view condo @ The Palace
May 3 – 10
$110 per night
Superhost
Resort in North Myrtle Beach
Tilghman Beach and Golf Resort 3 bed, 3 full bath
Dec 14 – 21
$161 per night
Superhost
Resort in Myrtle Beach
Oceanfront Resort with a View - Freshly Renovated
Jul 5 – 12
$199 per night
Guest favorite
Resort in Myrtle Beach
Beachfront condo ! Ocean Front !
Aug 14 – 21
$156 per night
Guest favorite
Room in Irmo
Relax in beach themed room. It's NOT snowing here!
Jul 23 – 30
$59 per night
Guest favorite
Resort in Myrtle Beach
Amazing Ocean views! Pool, lazy river, hot tub
Jun 3 – 10
$260 per night
Guest favorite
Resort in Myrtle Beach
Beautiful 2 bedroom resort at Myrtle Beach
Dec 11 – 18
$500 per night

Hotel rentals with a patio

Hotel room in Travelers Rest
Trailside Wedge
May 30 – Jun 6
$266 per night
Guest favorite
Room in Spartanburg
Lovely 1 br/1 private bath.
Apr 11 – 18
$70 per night
Guest favorite
Room in Anderson
The Michele Suite
May 31 – Jun 7
$61 per night
Guest favorite
Resort in Myrtle Beach
Beach Hideaway - Grande Cayman Resort MB *King bed
Apr 7 – 14
$180 per night
Guest favorite
Hotel in Hilton Head Island
Beautiful Baroney Beach Club
May 16 – 23
$928 per night
Superhost
Hotel in Hilton Head Island
Oceanfront suite at Surf Watch
$250 per night
Superhost
Hotel in North Myrtle Beach
2 BDR condo @ Ocean BLVD Wyndham
$399 per night
Superhost
Hotel in Myrtle Beach
Sheraton Broadway Resort - 2BD
Apr 22 – 29
$297 per night
Superhost
Hotel in North Charleston
The Starlight Motor Inn - Bunks!
Nov 11 – 18
$167 per night
Superhost
Hotel in North Myrtle Beach
Westwinds Resort - 2BR Unit
Jan 26 – Feb 2
$225 per night
Superhost
Hotel in Myrtle Beach
2 BR @ Ocean Watch Grand Dunnes
Jul 4 – 11
$749 per night
Superhost
Resort in Hilton Head Island
Delightful Resort Hilton Head
Dec 19 – 26
$196 per night

Destinations to explore